Micro-RNAs: small is plentiful.
Micro-RNAs: small is plentiful.
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DOI：
10.1083/jcb.200111033
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发表时间：
2002-01-07
影响因子：
7.8
通讯作者：
Slack, Frank J
中科院分区：
文献类型：
--
作者：
Grosshans, Helge;Slack, Frank J
大约22个核苷酸的两个小的暂时调节rna (stRNAs)*调节秀丽隐杆线虫发育过程中的基因表达时间。这种调控发生在转录后，可能是翻译水平，与RNA干扰（RNAi）不同。其中一种strna let-7及其靶基因lin-41即使在人类中也是高度保守的，这表明strna介导的基因调控被广泛使用。最近的报道表明，这两种strna确实可能只代表了后生动物中存在的数百种或更多附加的微rna （mirna）的冰山一角。因此，mirna可能是先前被低估的基因调控领域的关键参与者。
Two small temporally regulated RNAs (stRNAs)* of ∼22 nucleotides regulate timing of gene expression during development of the nematode C. elegans. This regulation occurs at a posttranscriptional, presumably translational, level and is distinct from RNA interference (RNAi). One of the two stRNAs, let-7, as well as its target gene, lin-41, are highly conserved even in humans, suggesting a wide employment of stRNA-mediated gene regulation. Recent reports indicate that these two stRNAs are indeed likely to represent only the tip of an iceberg with hundreds or more of additional micro-RNAs (miRNAs) existing in metazoans. miRNAs might thus be previously underestimated key participants in the field of gene regulation.