AFTERLOAD-INDUCED HOMEOMETRIC AUTOREGULATION IN ISOLATED CARDIAC-MUSCLE
AFTERLOAD-INDUCED HOMEOMETRIC AUTOREGULATION IN ISOLATED CARDIAC-MUSCLE
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DOI：
10.1152/ajplegacy.1976.231.2.545
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发表时间：
1976-01-01
影响因子：
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通讯作者：
HEFNER, LL
中科院分区：
文献类型：
--
作者：
DONALD, TC;PETERSON, DM;HEFNER, LL
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Pressure-induced homeometric autoregulation (HAR) was demonstrated in the mammalian ventricle. In isolated cardiac muscle the opposite effect (anti-HAR) was reported; namely, that the 1st beat after a transition from isotonic to isometric contraction is the most forceful, with a decline over several beats to a steady state. Trabeculae from the canine right ventricle demonstrate either HAR or anti-HAR, depending on the rate of stimulation, the Ca level and the temperature. Higher Ca, higher temperature and lower rate of stimulation produce either less HAR or more anti-HAR. When only temperature and rate of stimulation are varied, there is a unique rate for each temperature above which HAR occurs and below which anti-HAR occurs in each muscle.