Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.
Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.
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通过增加未连锁基因座的剂量来抑制果蝇的致死三体表型。
DOI：
10.1093/genetics/134.1.243
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发表时间：
1993
期刊：
影响因子：
3.3
通讯作者：
Christensen,AC
中科院分区：
文献类型：
--
作者：
Dorer,DR;Cadden,MA;Gordesky-Gold,B;Harries,G;Christensen,AC
基因剂量敏感性的一个最极端的例子是果蝇第三条染色体上的三倍致死基因座（Tpl），当它以一个或三个拷贝存在时是致命的。增加剂量的非连锁位点，Isis，抑制三倍致死表型的Tpl，但不是单倍致死表型。我们已经将Isis定位到X染色体区域7 E3 - 8A 5，并表明抑制是基因剂量效应。在存在两个Tpl拷贝的情况下，改变Isis的剂量没有明显的影响。通过研究Isis剂量和Tpl之间的相互作用，我们认为Isis不直接抑制Tpl表达，但作用于Tpl的三倍致死表型的下游。
One of the most extreme examples of gene dosage sensitivity is the Triplo-lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.