Controlled release and assembly of drug nanoparticles via pH-responsive polymeric micelles: a theoretical study.
Controlled release and assembly of drug nanoparticles via pH-responsive polymeric micelles: a theoretical study.
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DOI：
10.1021/jp3007816
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发表时间：
2012-05
期刊：
影响因子：
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通讯作者：
Guangkui Xu;Xi-Qiao Feng;Bo Li;Huajian Gao
中科院分区：
文献类型：
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作者：
Guangkui Xu;Xi-Qiao Feng;Bo Li;Huajian Gao
肿瘤组织的pH值通常低于正常组织，这种差异表明，利用pH控制的药物输送系统进行靶向癌症治疗是一种很有前途的方法。在平均场理论的基础上，我们提出了一种预测离子溶液中ph响应聚合物和纳米粒子自组装和自拆卸的理论方法。研究发现，在较窄的pH范围内，囊泡、圆柱形和球形胶束可以快速分解并释放所含的纳米颗粒。利用该模型进一步研究了显著提高包封效率的ph敏感药物的受控组装。该方法也适用于各种生物医学应用的控制递送纳米器件的设计。
Tumor tissues often have a pH value lower than normal tissues, and this difference suggests a promising way of targeted cancer therapy by using pH-controlled drug delivery systems. On the basis of the mean-field theory, we present a theoretical methodology to predict the self-assembly and disassembly of pH-responsive polymers and nanoparticles in an ionic solution. It is found that vesicles, cylindrical, and spherical micelles can rapidly disassemble and release contained nanoparticles in a narrow pH range. The model is further used to study the controlled assembly of pH-sensitive drug with significantly improved encapsulation efficiency. This method is also applicable for the design of controlled delivery nanodevices for various biomedical applications.