Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis
Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis
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DOI：
10.1634/theoncologist.2009-0289
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发表时间：
2010-09-01
期刊：
影响因子：
5.8
通讯作者：
Brenner, Hermann
中科院分区：
文献类型：
--
作者：
Pulte, Dianne;Brenner, Hermann
背景在过去的十年中，头颈部癌症的治疗已经发展，但很少有详细的分析，最近的发展，在人口水平上的生存率已经公布。我们使用周期分析和模型周期分析来揭示头颈癌患者生存率的近期趋势。数据来自监测、流行病学和最终结果有限使用数据库。结果。观察到生存率的重大统计学显著改善，总体5年相对生存率从1992-1996年的54.7%上升到2002-2006年的65.9%。亚组分析显示，口腔癌、舌癌、扁桃体癌和鼻咽癌的改善程度最高，其中扁桃体癌（+22.2个百分点）和舌癌（+14.4个百分点）的改善程度最高。对口腔癌、扁桃体癌和舌癌生存率的进一步分析显示，除年龄≥ 75岁的患者外，所有年龄组的各期生存率均有提高，其中局部晚期疾病和年龄55-64岁的舌癌和扁桃体癌以及年龄15-44岁的口腔癌患者的生存率提高最大。在过去的十年中，头颈癌患者的生存率大大提高。扁桃体癌和舌癌的改善最大。肿瘤学家2010;15：994-1001
Background. Therapy for head and neck cancers has evolved over the past decade, but few detailed analyses of recent developments in survival on the population level have been published.Methods. We use period analysis and modeled period analysis to disclose recent trends in survival in patients with head and neck cancer. Data are derived from the Surveillance, Epidemiology, and End Results limited-use database.Results. A major, statistically significant improvement in survival was observed, with the overall 5-year relative survival rate going from 54.7% in 1992-1996 to 65.9% in 2002-2006. Subgroup analysis showed improvement in cancers of the oral cavity, tongue, tonsils, and nasopharynx, with the greatest improvements observed in tonsillar carcinoma (+22.2 percentage points) and carcinoma of the tongue (+14.4 percentage points). Further analysis of survival for oral cavity, tonsillar, and tongue carcinoma revealed improvements in survival at each stage and across all age groups except for patients aged >= 75 years, with the greatest improvement occurring in locally advanced disease and in patients aged 55-64 years for carcinoma of the tongue and tonsils and those aged 15-44 years for oral cavity cancers.Conclusions. Survival has substantially improved for head and neck cancer patients over the past decade. The greatest improvement was seen in tonsillar and tongue cancers. The Oncologist 2010;15:994-1001