Epidemiology of Second Primary Tumors in Women With Ovarian Cancer
Epidemiology of Second Primary Tumors in Women With Ovarian Cancer
复制标题
DOI：
10.1097/igc.0000000000000950
复制
发表时间：
2017-05-01
影响因子：
4.8
通讯作者：
Witkin, Steven S.
中科院分区：
文献类型：
--
作者：
Kanninen, Tomi T.;Nasioudis, Dimitrios;Witkin, Steven S.
目的最后一项关于卵巢癌女性第二原发性肿瘤（SPTS）的大型研究发表于1996年，当时鉴别诊断和治疗尚未发生重大变化。本研究报告了诊断为卵巢癌的当代患者队列中SPT的发生率。方法从1992年至2012年期间诊断为卵巢恶性肿瘤的卵巢癌患者中确定并描述了监测，流行病学和最终结果数据库的13个登记处。1992年至2012年期间诊断为卵巢恶性肿瘤的073名女性中，1831名（4.5%）发生了显微镜证实的SPT。卵巢癌妇女和一般人群在所有部位发生SPT的风险没有显著差异。与一般监测、流行病学和最终结果人群相比，卵巢癌患者发生小肠、阴道、甲状腺和急性非淋巴细胞白血病的部位特异性SPT的风险升高。相反，患卵巢癌的妇女患肺和非霍奇金淋巴瘤的风险显著降低。在患有粘液性、类胶质瘤和生殖细胞肿瘤的女性中观察到SPT的风险升高。白色妇女有一个整体的风险降低发展第二原发性实体瘤，而美国印第安人和亚洲/太平洋岛民妇女有一个整体的风险增加了一个SPT在任何site.Conclusions的发病率在卵巢癌的妇女与一般人群相比，SPT没有显着不同。然而，观察到SPT的发生率与组织学、潜伏期、年龄和种族有关。
Objective The last large study of second primary tumors (SPTs) in women with ovarian cancer was published in 1996, prior to major changes in the differential diagnosis and treatment. The present study reports on the incidence of SPTs in a contemporary cohort of patients with a diagnosis of ovarian cancer.Methods Ovarian cancer patients with a diagnosis of an ovarian malignancy between 1992 and 2012 were identified and characterized from 13 registries of the Surveillance, Epidemiology, and End Results database.Results Of 41,073 women with a diagnosis of an ovarian malignancy between 1992 and 2012, 1831 (4.5%) developed a microscopically confirmed SPT. There was no significant difference in the risk of developing an SPT at all sites between women with an ovarian cancer and the general population. There was an elevated risk of site-specific SPTs of the small intestine, vagina, thyroid gland, and acute nonlymphocytic leukemia in ovarian cancer patients compared with the general Surveillance, Epidemiology, and End Results population. Conversely, the risk of lung and non-Hodgkin lymphoma was significantly decreased in women with ovarian cancer. An elevated risk of SPTs was observed in women with mucinous, endometrioid, and germ cell tumors. White women had an overall decreased risk of developing a second primary solid tumor, whereas American Indian and Asian/Pacific Islander women had an overall increased risk of an SPT at any site.Conclusions The incidence of SPTs in women with ovarian cancer was not significantly different as compared with the general population. However, divergent rates of SPTs in relation to histology, latency, age, and race were observed.