Cofilin phosphatases and regulation of actin dynamics
Cofilin phosphatases and regulation of actin dynamics
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DOI：
10.1016/j.ceb.2005.11.005
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发表时间：
2006-02-01
影响因子：
7.5
通讯作者：
Bokoch, GM
中科院分区：
文献类型：
--
作者：
Huang, TY;DerMardirossian, C;Bokoch, GM
Cofilin是一种普遍存在的肌动蛋白结合因子，在真核生物中肌动蛋白丝的重组所需的。cofilin的去磷酸化使其肌动蛋白切割和解聚活性，并驱动定向细胞运动，从而为肌动蛋白重组提供了一个简单的磷酸化调节机制。迄今为止，已经鉴定了两种cofilin特异性磷酸酶：Slingshot和Chronophin。这些cofilin磷酸酶在序列和调节特性上是不相关的，每种都可能在不同的生物学环境下为cofilin激活提供独特的机制。
Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances.