Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity
Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity
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DOI：
10.3978/j.issn.2078-6891.2010.025
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发表时间：
2011-06-01
影响因子：
2.1
通讯作者：
Lenz, Heinz-Josef
中科院分区：
文献类型：
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作者：
Yang, Dongyun;Hendifar, Andrew;Lenz, Heinz-Josef
背景资料：尽管现代化疗在大肠癌的治疗中取得了成功，但转移性胃癌患者的结局仍然令人沮丧。识别预测和预后标志物是一个重要的步骤，以改善目前的治疗方法和延长survival.Methods：提取数据从美国国家癌症研究所的监测，流行病学和最终结果（SEER）登记处，我们比较了转移性胃癌患者的总生存率的性别，年龄和种族使用考克斯比例风险模型。从1988年至2004年确定了13，840例患者（>= 18岁）。男性和女性按年龄组和种族进行分类。结果：19%的西班牙裔患者被诊断为< 45岁，而白人为5.5%。白人患者和男性更容易被诊断为贲门肿瘤（P
Background: Despite the success of modern chemotherapy in the treatment of large bowel cancers, patients with metastatic gastric cancer continue to have a dismal outcome. Identifying predictive and prognostic markers is an important step to improving current treatment approaches and extending survival.Methods: Extracting data from the US NCI's Surveillance, Epidemiology, and End Results (SEER) registries, we compared overall survival for patients with metastatic gastric cancer by gender, age, and ethnicity using Cox proportional hazards models. 13,840 patients (>= 18 years) were identified from 1988-2004. Males and females were categorized by age grouping and ethnicity.Results: 19% of Hispanic patients were diagnosed < 45 years of age as compared to 5.5% of Caucasians. Caucasian patients and men were more likely to be diagnosed with tumors in the gastric cardia (P