Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators.
Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators.
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DOI：
10.1002/anie.200905933
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发表时间：
2010-02-01
影响因子：
16.6
通讯作者：
Oldfield, Eric
中科院分区：
文献类型：
--
作者：
Zhang, Yonghui;Cao, Rong;Yin, Fenglin;Lin, Fu-Yang;Wang, Hong;Krysiak, Kilannin;No, Joo-Hwan;Mukkamala, Dushyant;Houlihan, Kevin;Li, Jikun;Morita, Craig T.;Oldfield, Eric
Bisphosphonates such as risedronate and ibandronate are widely used to treat a variety of bone resorption diseases, preventing protein prenylation and disrupting osteoclast function.[1] Bisphosphonates also activate human gδ T cells (expressing the Vg2Vd2 T cell receptor), and these activated gδ T cells kill tumor cells.[2, 3] There has thus been interest in using bisphosphonates in cancer immunotherapy, with promising results against B-cell malignancies [4] and hormone refractory prostate cancer.[5] In a very recent clinical trial, it was shown that zoledronate offered a significant anticancer benefit when added to hormone therapy, reducing the risk of cancer returning by 36%.[6] The bisphosphonates used in these trials are, however, extremely polar and are rapidly removed from circulation by binding to bone. We reasoned that it might be possible to develop more lipophilic bisphosphonates [7] as gδ T cell stimulators that would have improved cell uptake properties as well as decreased bone binding affinity.[8] Herein, we report that novel lipophilic pyridinium bisphosphonates are approximately 250 times more effective in gδ T cell activation than any other bisphosphonate drugs.
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影响因子：
11.2
作者：
Dieli F;Vermijlen D;Fulfaro F;Caccamo N;Meraviglia S;Cicero G;Roberts A;Buccheri S;D'Asaro M;Gebbia N;Salerno A;Eberl M;Hayday AC
通讯作者：
Hayday AC
影响因子：
3.5
作者：
Wiemer, Andrew J.;Yu, Jose S.;Wiemer, David F.
通讯作者：
Wiemer, David F.
DOI：
10.1196/annals.1402.089
发表时间：
2007-01-01
期刊：
SKELETAL BIOLOGY AND MEDICINE, PT B
影响因子：
--
作者：
Russell, R. Graham G.;Xia, Zhidao;Ebetino, Frank H.
通讯作者：
Ebetino, Frank H.
影响因子：
6.5
作者：
Roelofs AJ;Jauhiainen M;Mönkkönen H;Rogers MJ;Mönkkönen J;Thompson K
通讯作者：
Thompson K
影响因子：
6.2
作者：
Thompson, K;Rogers, MJ
通讯作者：
Rogers, MJ