TRANSCRIPTS OF THE 6 DROSOPHILA ACTIN GENES ACCUMULATE IN A STAGE-SPECIFIC AND TISSUE-SPECIFIC MANNER
TRANSCRIPTS OF THE 6 DROSOPHILA ACTIN GENES ACCUMULATE IN A STAGE-SPECIFIC AND TISSUE-SPECIFIC MANNER
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DOI：
10.1016/0092-8674(83)90340-9
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发表时间：
1983-01-01
期刊：
影响因子：
64.5
通讯作者：
DAVIDSON, N
中科院分区：
文献类型：
--
作者：
FYRBERG, EA;MAHAFFEY, JW;DAVIDSON, N
研究了果蝇肌动蛋白基因在个体发育过程中的表达。克隆的肌动蛋白基因的独特部分用于监测发育阶段的整个生物体和解剖的身体部位中各自的mRNA水平。每个基因被转录形成功能性mRNA，其以不同的模式积累。其中两个基因act 5C和act 42 A在未分化细胞中表达，可能编码细胞质肌动蛋白。Act 57 A和act 87 E主要在幼虫、蛹和成虫的节间肌肉中表达; act 88 F在成虫的胸部肌肉中表达，而act 79 B在胸部和腿部肌肉中表达。这些复合数据定义了肌动蛋白基因表达的3种主要模式，这些模式与果蝇形态学的变化，特别是肌肉分化和重组相关。
Expression of the 6 Drosophila actin genes was surveyed during ontogeny. Unique portions of cloned actin genes were used to monitor levels of respective mRNA in developmentally staged whole organisms and dissected body parts. Each gene is transcribed to form functional mRNA, which accumulates with a distinct pattern. Two of the genes act5C and act42A, are expressed in undifferentiated cells and probably encode cytoplasmic actins. Act57A and act87E are expressed predominantly in larval, pupal and adult intersegmental muscles; act88F in muscles of the adult thorax, and act79B in the thorax and leg muscles. These composite data define 3 main patterns of actin gene expression which are correlated with changing Drosophila morphology, particularly muscle differentiation and reorganization.