REINNERVATION OF THE HIPPOCAMPAL PERFORANT PATHWAY ZONE IN ALZHEIMERS-DISEASE
REINNERVATION OF THE HIPPOCAMPAL PERFORANT PATHWAY ZONE IN ALZHEIMERS-DISEASE
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DOI：
10.1002/ana.410210307
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发表时间：
1987-03-01
影响因子：
11.2
通讯作者：
VANHOESEN, GW
中科院分区：
文献类型：
--
作者：
HYMAN, BT;KROMER, LJ;VANHOESEN, GW
穿孔通路起源于海马前旁回的内嗅皮层，终止于齿状回颗粒细胞的外树突分支和枕下及海马的锥体细胞。它将主要的皮层输入传递到海马区。在实验动物中，穿孔通路的破坏会导致其目标神经元的部分传入神经失传，随后乙酰胆碱酯酶（AChE）末端在失传入穿孔通路区大量涌现。在阿尔茨海默病中，穿孔通路的起源细胞充满了神经原纤维缠结。在阿尔茨海默病的穿孔通路终末区，乙酰胆碱酯酶染色显示出在对照脑中没有发现的几种不同的模式。这些变化与实验研究结果一致，证明了实验室哺乳动物，包括非人灵长类动物的神经再生。结果表明，在阿尔茨海默氏病中，含有痛觉性疼痛系统的萌芽发生在海马体形成中，以响应疾病相关的内嗅皮层细胞损伤。
The perforant pathway originates from the entorhinal cortex of the anterior parahippocampal gyrus and terminates on the outer dendritic branches of the granule cells of the dentate gyrus and pyramidal cells of the subiculum and hippocampus. It carries the principal cortical input to the hippocampal formation. Destruction of the perforant pathway in experimental animals leads to a partial deafferentation of its target neurons, followed by a robust sprouting of acetylcholinesterase (AChE) terminals in the deafferented perforant pathway zone. In Alzheimer''s disease, the cells of origin of the perforant pathways are laden with neurofibrillary tangles. AChE staining in the terminal zone of the perforant pathway in Alzheimer''s disease shows several distinct patterns that are not found in control brains. These changes are consistent with the results of experimental studies demonstrating reinnervation in laboratory mammals, including nonhuman primates. The results suggest that in Alzheimer''s disease sprouting of AChE-containing systems occurs in the hippocampal formation in response to disease-related cellular damage in the entorhinal cortex.