Repeatability of corneal epithelial thickness measurements using Fourier-domain optical coherence tomography in normal and post-LASIK eyes.
Repeatability of corneal epithelial thickness measurements using Fourier-domain optical coherence tomography in normal and post-LASIK eyes.
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DOI：
10.1097/ico.0b013e3182a7f39d
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发表时间：
2013-12
期刊：
影响因子：
2.8
通讯作者：
Koch DD
中科院分区：
文献类型：
--
作者：
Ma XJ;Wang L;Koch DD
目的评价光学相干断层扫描(OCT、RTVue)测量正常眼和LASIK眼角膜上皮厚度(ET)和角膜厚度(CT)的可重复性。对35名正常人的35只右眼和45名既往近视LASIK患者的45只右眼进行了17个区域的角膜ET和CT检查：1)1个0~2.0 mm直径的中心区；2)2.0~5.0 mm的8个旁中心区；3)5.0~6.0 mm的8个周边区。重复性用受试者内标准差(SD)、变异系数(CoV)和组内相关系数(ICC)进行评估。正常眼和准分子激光原位角膜磨镶术中心区和旁中心区的SD值分别为0.7μm和0.6~0.9μm和0.7μm和0.8~1.7μm，CT分别为1.0μm和2.8~4.6μm和1.3μm和4.0~4.8μm。在周边区，正常眼和准分子激光屈光性手术眼的标准差分别为0.8~1.2μm和1.4~2.2μm，CT为4.1~6.4μm和6.0~9.1μm。在ET和CT测量中，两组的COV值都较低，而ICC值较高。OCT具有良好的重复性，特别是在中央和中央附近直径达5 mm的区域，用于测量角膜上皮厚度和角膜厚度。
To evaluate the repeatability of corneal epithelial thickness (ET) and corneal thickness (CT) measurements in normal and LASIK eyes using the optical coherence tomography (OCT, RTVue). In 35 right eyes of 35 normal subjects and 45 right eyes of 45 subjects with prior myopic LASIK, corneal ET and CT were evaluated in 17 areas: 1) one central zone within 0-2.0 mm diameter, 2) eight paracentral zones from 2.0-5.0 mm diameter, and 3) eight peripheral zones from 5.0-6.0 mm diameter. The repeatability was assessed using within-subject standard deviation (SD), coefficient of variation (CoV), and intraclass correlation coefficient (ICC). At the central and paracentral zones, respectively, the SD values were 0.7 μm and 0.6-0.9 μm in normal eyes and 0.7 μm and 0.8-1.7 μm in LASIK eyes for ET, and 1.0 μm and 2.8-4.6 μm in normal eyes and 1.3 μm and 4.0-4.8 μm in LASIK eyes for CT. At the peripheral zones, in normal and LASIK eyes, respectively, SD values ranged from 0.8-1.2 μm and 1.4-2.2 μm for ET, and 4.1-6.4 μm and 6.0-9.1 μm for CT. The CoV values were low and ICC values were high in both groups for both ET and CT measurements. The OCT produced excellent repeatability, especially at the central and paracentral zones up to 5-mm diameter for both corneal epithelial thickness and corneal thickness measurements.