On the feasibility to detect and to quantify prepulse-elicited reaction in prepulse inhibition of the acoustic startle reflex in humans
On the feasibility to detect and to quantify prepulse-elicited reaction in prepulse inhibition of the acoustic startle reflex in humans
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DOI：
10.1016/j.bbr.2005.03.020
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发表时间：
2005-07-30
影响因子：
2.7
通讯作者：
Yee, BK
中科院分区：
文献类型：
--
作者：
Csomor, PA;Vollenweider, FX;Yee, BK
最近，人们对前脉冲抑制（PPI）研究中通常采用的前脉冲刺激产生可观察反应的可能性提出了质疑。相互矛盾的报告范围从对前脉冲引起的惊吓反应的观察到在健康志愿者中完全没有可检测到的前脉冲引起的反应。这一争议在本研究中受到严格审查。在两个独立的实验中，使用高于背景 6 至 18 dB（实验 1）或高于背景 1 至 5 dB（实验 2）的预脉冲，检查了预脉冲刺激诱导 PPI 和引发可测量反应的能力。采用三个级别的脉冲刺激：95、105 和 115 dB(A)。实验 1 获得了清晰的 PPI 和前脉冲诱发反应，而实验 2 中两种效果均不明显。强度足以诱发可靠 PPI 的非惊吓预脉冲与可检测和可量化的反应相关，证实直接评估前脉冲处理是可行和实用的。这为 PPI 的理论和潜在临床相关性提供了额外的衡量标准，并且应该将其纳入未来针对患者和健康受试者的研究中。 (c) 2005 Elsevier B.V. 保留所有权利。
The possibility that the prepulse stimulus typically employed in the studies of prepulse inhibition (PPI) can produce observable response has been questioned recently. Conflicting reports range from observations of prepulse-elicited startle reaction to a complete lack of detectable prepulse-elicited reactions in healthy volunteers. This controversy is subjected to critical examination in the present study. The ability of prepulse stimuli to induce PPI and to elicit measurable responses was examined in two separate experiments using prepulses ranging from 6 to 18 dB above background (experiment 1), or I to 5 dB above background (experiment 2). Three levels of pulse stimulus were employed: 95, 105 and 115 dB(A). Clear PPI and prepulse-elicited reaction were obtained in experiment 1, while neither effect was evident in experiment 2. Non-startle-eliciting prepulses that are of sufficient intensities to induce reliable PPI are associated with detectable and quantifiable response, confirming that direct evaluation of prepulse-processing is feasible and practical. This provides an additional measure of theoretical and potentially clinical relevance to PPI, and it ought to be included in future studies in patients as well as healthy subjects. (c) 2005 Elsevier B.V. All rights reserved.