Novel biologics targeting the P2X7 ion channel
Novel biologics targeting the P2X7 ion channel
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DOI：
10.1016/j.coph.2019.03.001
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发表时间：
2019-08-01
影响因子：
4
通讯作者：
Adriouch, Sahil
中科院分区：
文献类型：
--
作者：
Koch-Nolte, Friedrich;Eichhoff, Anna;Adriouch, Sahil
Targeting the P2X7 ion channel, a danger sensor for extracellular nucleotides, improves outcomes in models of inflammation, cancer, and brain-diseases. Antibodies and nanobodies have been developed that antagonize or potentiate gating of P2X7. Their potential advantages over small-molecule drugs include high specificity, lower off-target effects, and tunable in vivo half-life. Genetic fusion of P2X7-specific biologics to binding modules may enable targeting of specific cell subsets. Besides directly modulating P2X7 function, antibodies can also initiate specific depletion of P2X7-expressing cells. Adeno-associated viral vectors (AAV) can be used to express P2X7-specific antibodies in vivo to achieve long-lasting biological effects. Furthermore, if successfully targeted to P2X7-expressing cells, AAVs may enable modulation of the function of P2X7-expressing immune cells via encoded transgenic RNA or proteins.
