Sex differences in brain maturation in maltreatment-related pediatric posttraumatic stress disorder
Sex differences in brain maturation in maltreatment-related pediatric posttraumatic stress disorder
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DOI：
10.1016/s0149-7634(03)00013-7
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发表时间：
2003-01-01
影响因子：
8.2
通讯作者：
Keshavan, MS
中科院分区：
文献类型：
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作者：
De Bellis, MD;Keshavan, MS
背景最近的调查表明，儿童创伤后应激障碍（PTSD）与大脑发育不良有关。然而，性别差异的理解很差。在这项研究中，61名医学上健康的儿童和青少年（31名男性和30名女性）患有慢性创伤后应激障碍继发于虐待，他们有类似的创伤和精神健康史，和122名健康对照（62名男性和60名女性）进行了全面的精神评估和解剖MRI脑扫描。当性别组分别进行分析时，与性别匹配的对照受试者相比，在虐待相关PTSD的男孩和女孩中均发现前额叶CSF体积较大，胼胝体亚区7（压部）的中矢状面面积较小。与非虐待受试者相比，PTSD受试者的总胼胝体及其第7区（压部）面积未显示出正常的年龄相关性增加;然而，这一发现在PTSD男性中更为突出。显著的性别组效应显示PTSD男性患者的脑体积和胼胝体I区（喙部）和6区（峡部）较小，而PTSD男性患者的侧脑室体积增加大于PTSD女性患者。这些数据表明，有虐待相关的创伤后应激障碍的男孩和女孩的大脑成熟的性别差异。儿童期PTSD的纵向MRI脑调查和性别与心理社会结果的关系是必要的。(C)2003爱思唯尔科技有限公司版权所有。
Background. Recent investigations suggested that pediatric posttraumatic stress disorder (PTSD) is associated with adverse brain development. However, sex differences are poorly understood.Methods. In this study, 61 medically healthy children and adolescents (31 males and 30 females) with chronic PTSD secondary to abuse, who had similar trauma and mental health histories, and 122 healthy controls (62 males and 60 females) underwent comprehensive psychiatric assessments and an anatomical MRI brain scan.Results. When gender groups were analyzed separately, findings of larger prefrontal lobe CSF volumes and smaller midsagittal area of the corpus callosum subregion 7 (splenium) were seen in both boys and girls with maltreatment-related PTSD compared to their gender-matched comparison subjects. Subjects with PTSD did not show the normal age related increases in the area of the total corpus callosum and its region 7 (splenium) compared to non-maltreated subjects; however, this finding was more prominent in males with PTSD. Significant sex by group effects demonstrated smaller cerebral volumes and corpus callosum regions I (rostrum) and 6 (isthmus) in PTSD males and greater lateral ventricular volume increases in maltreated males with PTSD than maltreated females with PTSD.Conclusions. These data suggest that there are sex differences in the brain maturation of boys and girls with maltreatment-related PTSD. Longitudinal MRI brain investigations of childhood PTSD and the relationship of gender to psychosocial outcomes are warranted. (C) 2003 Elsevier Science Ltd. All rights reserved.