Asymptomatic children with epilepsy
Asymptomatic children with epilepsy
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无症状癫痫儿童
DOI：
10.1212/wnl.36.6.838
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发表时间：
1986
期刊：
影响因子：
9.9
通讯作者：
J. Tibbies
中科院分区：
文献类型：
--
作者：
C. Camfield;P. Camfield;Edythe Smith;J. Tibbies
在一项前瞻性研究中，我们对199名接受抗惊厥药物治疗的无症状儿童进行了肝、肾和血液学毒性的常规筛查。在0 - 24个月期间进行尿分析、CBC、分类计数、血小板、SGOT、胆红素和碱性磷酸酶（在使用丙戊酸盐的患者中，还包括淀粉酶和纤维蛋白原）。依从性极佳。尿液总是正常的。百分之六的患者有短暂的轻微异常的血液研究需要复查。重复检查均正常。两个孩子有重大的血液异常识别，导致药物的变化，被证明是不必要的。基线测定和对毒性症状的及时关注应取代常规的血液和尿液筛查。
In a prospective study of 199 asymptomatic children receiving anticonvulsant drugs, we evaluated routine screening for liver, renal, and hematologic toxicity. Urinalysis, CBC, differential, platelets, SGOT, bilirubin, and alkaline phosphatase (plus amylase and fibrinogen in patients taking valproate) were obtained between 0 and 24 months. Compliance was excellent. Urine was always normal. Six percent of patients had transient minor abnormalities of blood studies necessitating rechecks. All were normal on repeat. Two children had major blood abnormalities recognized, leading to drug changes that proved to have been unnecessary. Baseline determinations and prompt attention to symptoms of toxicity should replace routine screening of blood and urine.