Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study
Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study
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DOI：
10.5152/akd.2011.132
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发表时间：
2011-09-01
影响因子：
1.3
通讯作者：
Uyarel, Huseyin
中科院分区：
文献类型：
--
作者：
Buturak, Ali;Genc, Ahmet;Uyarel, Huseyin
目的：为评价慢性生物质燃料（BMF）烟雾暴露对外周血管内皮功能的影响，选取47例出生后长期暴露于BMF烟雾的健康受试者（平均年龄31.6 ± 6.8岁，男性21例），进行横断面观察研究。对照组包括32名健康受试者（平均年龄27.9 ± 4.4岁，11名男性）。测量颈动脉内膜中层厚度（CIMT）、血流相关性舒张功能（FAD %）和内皮非依赖性血管舒张功能（GTN %）。颈动脉CIMT定义为管腔内膜前缘与中膜外膜界面之间的距离。FAD %定义为反应性充血期间肱动脉内径相对于基线的百分比变化。GTN %定义为在第四分钟结束时，相对于基线扫描，响应于400 μ g三硝酸甘油的应用的直径变化。统计分析采用学生t检验，卡方检验和斯皮尔曼等级顺序相关性analysis.Results：受试者的平均暴露时间为31.7 +/- 6.6年的生物质燃料烟雾。他们在一年中季节性地平均暴露于粪吸入产品8.3 +/-1.8个月。平均每日暴露时间为15.7 +/- 3.3小时。两组的CIMT值无统计学差异（0.47 +/- 0.09 vs. 0.49 +/- 0.06 mm，p=0.138）。然而，在研究组中确定了显著降低的FAD %（5.06 +/- 4.95 vs. 10.7 +/- 4.64，p < 0.001）。BMF组的FAD %和GTN %显著低于对照组（14.41 ± 8.47vs.21.85 ± 7.87，p < 0.001）。因此，慢性BMF烟雾暴露可能是内皮功能障碍发展的危险因素。（Anadolu Kardiyol Derg 2011; 11：492-7）
Objective: To evaluate the effect of chronic biomass fuel (BMF) smoke exposure on peripheral endothelial functions.Methods: Forty-seven healthy subjects who have been exposed to BMF smoke since birth (mean age 31.6 +/- 6.8 years, 21 male) were enrolled in the present cross-sectional observational study. The control group consisted of 32 healthy subjects (mean age 27.9 +/- 4.4 years, 11 male). The carotid intima media thickness (CIMT), flow associated dilatation (FAD %) and endothelium independent vasodilatation (GTN %) were assessed in all subjects. The carotid CIMT was defined as the distance between the leading edge of the lumen intima and the media adventitia interfaces. FAD % was defined as the percentage change in the internal diameter of the brachial artery during reactive hyperemia related to the baseline. GTN % was defined as the change in diameter in response to the application of 400 mu g of glyceril trinitrate relative to the baseline scan at the end of the fourth minute. Statistical analysis was performed using Student's t-test, Chi-square test and Spearman rank order correlation analysis.Results: The average exposure time of the subjects to biomass fuel smoke was 31.7 +/- 6.6 years. They have been exposed to dung inhalation products meanly 8.3 +/- 1.8 months in a year seasonally. The average daily exposure time was 15.7 +/- 3.3 hours. CIMT values of the two groups were not statistically different from each other (0.47 +/- 0.09 vs. 0.49 +/- 0.06 mm, p=0.138). However, a markedly reduced FAD % was determined in the study group (5.06 +/- 4.95 vs. 10.7 +/- 4.64, p < 0.001). And GTN % of the BMF exposed group was significantly lower than the control group (14.41 +/- 8.47 vs. 21.85 +/- 7.87, p < 0.001).Conclusion: FAD % and GTN % are markedly reduced in the individuals who have been exposed to BMF smoke inhalation products. Therefore, chronic BMF smoke exposure may be a risk factor for the development of endothelial dysfunction. (Anadolu Kardiyol Derg 2011; 11:492-7)