Specific small-molecule NIR-II fluorescence imaging of Osteosarcoma and lung metastasis
Specific small-molecule NIR-II fluorescence imaging of Osteosarcoma and lung metastasis
复制标题
骨肉瘤和肺转移的特异性小分子 NIR-II 荧光成像
DOI：
10.1002/adhm.201901224
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发表时间：
2020
影响因子：
10
通讯作者：
Hong Xuechuan
中科院分区：
文献类型：
--
作者：
Zhou Hui;Yi Wanrong;Li Anguo;Wang Bo;Ding Qihang;Xue Liru;Zeng Xiaodong;Feng Yanzhi;Li Qianqian;Wang Tian;Li Yang;Cheng Xiaoding;Tang Lin;Deng Zixin;Wu Mingfu;Xiao Yuling;Hong Xuechuan
骨肉瘤是一种侵袭性间充质肿瘤，比其他肿瘤更容易扩散到肺部，对患者的预后有重大影响。能够可靠地检测或排除骨肉瘤肺转移的最佳影像学方法仍然很少。本文设计并合成了两种同源荧光探针ch1055‐PEG‐PTandCH1055‐PEG‐附着体，它们分别在骨肉瘤及其肺转移的靶向成像中显示出很高的前景。我们发现ch1055 - PEG - PTis的近红外成像质量远优于计算机断层扫描，用于早期体内143B肿瘤的成像，并进一步进行探针引导的143B肿瘤精确切除手术。还证明了使用ch1055 - PEG -附着体对骨肉瘤的原发性和微转移性肺病变的高分辨率可视化。因此，ch1055 - PEG - PTandCH1055 - PEG -附着体具有高水平的吸收和高空间和时间分辨率的成像特性，为骨肉瘤及其肺转移的分子成像和临床转化提供了独特的第二近红外窗口。
Osteosarcoma is an aggressive tumor of mesenchymal origin that is more likely to spread to the lung than others, with a major impact on patients' prognosis. The optimal imaging method that can reliably detect or exclude pulmonary metastases from osteosarcoma is still scarce. Herein, two homologous types of fluorescent probesCH1055‐PEG‐PTandCH1055‐PEG‐Affibody, which show highly promising results for targeting imaging of osteosarcoma and its lung metastasis, respectively, are designed and synthesized. It is found that the NIR‐II imaging quality ofCH1055‐PEG‐PTis far superior to that of computed tomography for the early in vivo 143B tumor imaging, and this probe‐guided surgery for accurate resection of 143B tumor is further performed. The high‐resolution visualization of primary and micrometastatic lung lesions of osteosarcoma by usingCH1055‐PEG‐Affibodyis also demonstrated. Therefore, the attractive imaging properties ofCH1055‐PEG‐PTandCH1055‐PEG‐Affibody, including high levels of uptakes, and high spatial and temporal resolution, open up opportunities for molecular imaging and clinical translation of osteosarcoma and its lung metastasis in the unique second near‐infrared window.