Towards personalised management of atherosclerosis via computational models in vascular clinics: technology based on patient-specific simulation approach.
Towards personalised management of atherosclerosis via computational models in vascular clinics: technology based on patient-specific simulation approach.
复制标题
通过血管诊所中的计算模型对动脉粥样硬化的个性化管理：基于患者特定模拟方法的技术。
DOI：
10.1049/htl.2013.0040
复制
发表时间：
2014-01
影响因子：
2.1
通讯作者：
Pichardo-Almarza C
中科院分区：
文献类型：
--
作者：
Díaz-Zuccarini V;Di Tomaso G;Agu O;Pichardo-Almarza C
介绍了一种基于患者特异性模型的新技术的开发，用于动脉粥样硬化患者的个性化医疗保健。动脉粥样硬化是世界上主要的死亡原因，由于其表现形式多种多样，如冠状动脉疾病、脑血管疾病/中风和外周动脉疾病，它已成为临床服务的负担。这也是一个持续一生的多因素、慢性和系统性过程，给国家卫生系统带来巨大的财务和临床压力。在这封信中，假设未来可以将使用计算机模拟的医疗保健新技术开发为计算机管理和支持系统。这些新技术将基于预测模型（包括跨时空尺度、科学学科、关键风险因素和解剖子系统的观察、理论和预测的整合），并结合数字患者数据和可视化工具。尽管问题极其复杂，但仍提出了此类技术在临床上的模拟工作流程和示例应用，目前由多学科团队根据伦敦大学学院医院血管服务部门的要求和限制进行开发。
The development of a new technology based on patient-specific modelling for personalised healthcare in the case of atherosclerosis is presented. Atherosclerosis is the main cause of death in the world and it has become a burden on clinical services as it manifests itself in many diverse forms, such as coronary artery disease, cerebrovascular disease/stroke and peripheral arterial disease. It is also a multifactorial, chronic and systemic process that lasts for a lifetime, putting enormous financial and clinical pressure on national health systems. In this Letter, the postulate is that the development of new technologies for healthcare using computer simulations can, in the future, be developed as in-silico management and support systems. These new technologies will be based on predictive models (including the integration of observations, theories and predictions across a range of temporal and spatial scales, scientific disciplines, key risk factors and anatomical sub-systems) combined with digital patient data and visualisation tools. Although the problem is extremely complex, a simulation workflow and an exemplar application of this type of technology for clinical use is presented, which is currently being developed by a multidisciplinary team following the requirements and constraints of the Vascular Service Unit at the University College Hospital, London.