Prediction of drug clearance in humans from laboratory animals based on body surface area
Prediction of drug clearance in humans from laboratory animals based on body surface area
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DOI：
10.1007/bf03226379
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发表时间：
2001-10-01
影响因子：
1.9
通讯作者：
Chen, J
中科院分区：
文献类型：
--
作者：
Liu, XD;Chen, J
该研究的目的是开发一种新的基于体表面积的从实验动物到人类的清除异速方程（BSA异速生长法）。根据文献中获得的动物数据预测了 30 种药物的人体清除率。将用该方法预测的结果与观察到的结果进行比较。结果还分别与清除率与体重的预测值（BW简单异速生长法）、脑重量和清除率与体重的乘积（Cl X BRW法）以及最大寿命潜力和清除率与体重的乘积（Cl X MLP法）进行比较。使用 BAS 异速生长方法，30 例中有 21 例得到了良好的预测。 BSA 异速生长法和 BW 简单异速生长法都可以很好地预测许多药物在人体中的清除率。与BW简单异速生长法、Cl X BRW法和Cl X MLP法类似，BSA异速生长法可用于根据实验动物数据准确预测人体清除率。
The object of the study was to develop a new allometric equation for clearance from laboratory animals to humans based on body surface area(BSA allometric method). Human clearances for 30 drugs were predicted from animal data obtained from the literature. The results predicted with the method were compared with those observed. The results were also compared with values predicted with clearance versus body weight (BW simple allometric method), the product of brain weight and clearance versus body weight(Cl X BRW method) and the product of maximum life span potential and clearance versus body weight (Cl X MLP method), respectively. Good predictions were found in 21 out of 30 with the BAS allometric method. Both BSA allometric method and BW simple allometric method can give good predictions of clearance in humans for many drugs. Similarly to BW simple allometric method, Cl X BRW method and Cl X MLP method, BSA allometric method may be used to accurately predict human clearance from laboratory animal data.