Structural imaging in premanifest and manifest Huntington disease
Structural imaging in premanifest and manifest Huntington disease
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DOI：
10.1016/b978-0-12-801893-4.00020-1
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Aylward, Elizabeth H.
中科院分区：
文献类型：
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作者：
Scahill, Rachael I.;Andre, Ralph;Aylward, Elizabeth H.
亨廷顿病（HD）神经病理学对脑结构和脑功能具有破坏性影响;神经影像学提供了一种评估基因携带者这些影响的方法。在这一章中，我们首先概述了独特的效用结构成像在理解HD和讨论一些收购和分析技术目前可用。我们回顾了现有的文献，总结了我们所知道的迄今为止的结构性脑变化的疾病谱，从预显到显着的疾病。然后，我们考虑这些神经影像学发现如何与患者功能和非影像学生物标志物相关，并可用于预测疾病发作。最后，我们回顾了临床试验中评估治疗效果的成像措施的效用。
Huntington disease (HD) neuropathology has a devastating effect on brain structure and consequently brain function; neuroimaging provides a means to assess these effects in gene carriers. In this chapter we first outline the unique utility of structural imaging in understanding HD and discuss some of the acquisition and analysis techniques currently available. We review the existing literature to summarize what we know so far about structural brain changes across the spectrum of disease from premanifest through to manifest disease. We then consider how these neuroimaging findings relate to patient function and non-imaging biomarkers, and can be used to predict disease onset. Finally we review the utility of imaging measures for assessment of treatment efficacy in clinical trials.