Time-dependent changes in the serum levels of prolactin, nesfatin-1 and ghrelin as a marker of epileptic attacks young male patients
Time-dependent changes in the serum levels of prolactin, nesfatin-1 and ghrelin as a marker of epileptic attacks young male patients
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DOI：
10.1016/j.peptides.2011.04.021
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发表时间：
2011-06-01
期刊：
影响因子：
3
通讯作者：
Catak, Zekiye
中科院分区：
文献类型：
--
作者：
Aydin, Suleyman;Dag, Ersel;Catak, Zekiye
据报道，在动物和人类中，荷尔蒙和癫痫发作之间存在关系。因此，本研究的目的是调查癫痫发作或非癫痫事件后不同时间测定的血清催乳素、Nesfatin-1和Ghrelin水平之间的关系，并与对照组进行比较。研究对象为70例受试者，其中继发性全面性癫痫(SGE)18例，原发全面性癫痫(PGE)16例，发作性事件(心理性)16例，健康男性20例。第一个样本是在癫痫发作后5分钟内采集的，在1、24和48小时后再采集样本，只要患者没有表现出进一步的临床可观察到的癫痫发作；从对照受试者身上采集一次血液样本。用Tosoh生物科学激素测定仪立即测定催乳素。用商品免疫试剂盒检测Nesfatin-1和Ghrelin多肽。继发性全面性癫痫和原发全面性癫痫患者发作后5分钟、1小时和24小时血清催乳素和生长素-1水平显著高于有发作性发作事件(心因性)患者和对照组，48h后差异无统计学意义。本研究提示，血清催乳素和尼斯非汀-1水平升高，生长素水平降低可作为近期癫痫发作或其他发作性事件(心因性)患者的标志物。(C)2011 Elsevier Inc.保留所有权利。
A relationship between hormones and seizures has been reported in animals and humans. Therefore, the purpose of this study was to investigate the association between serum levels of prolactin, nesfatin-1 and ghrelin measured different times after a seizure or non-epileptic event and compared with controls. The study included a total of 70 subjects, and of whom 18 patients had secondary generalized epilepsy (SGE), 16 patients had primary generalized epilepsy (PGE), 16 patients exhibited paroxysmal event (psychogenic) and 20 healthy males were control subjects. The first sample was taken within 5 min of a seizure, with further samples taken after 1, 24, and 48 h so long as the patient did not exhibit further clinically observable seizures; blood samples were taken once from control subjects. Prolactin was measured immediately using TOSOH Bioscience hormone assays. Nesfatin-1 and ghrelin peptides were measured using a commercial immunoassay kit. Patients suffering from focal epilepsy with secondary generalization and primary generalized epilepsy presented with significantly higher levels of serum prolactin and nesfatin-1 and lower ghrelin levels 5 min, 1 and 24 h after a seizure than patients presenting with paroxysmal events (psychogenic) and control subjects; the data were sirnilar but not statistically significant after 48 h. The present study suggests that increased serum prolactin and nesfatin-1 concentrations, decreased ghrelin concentrations could be used as markers to identify patients that have suffered a recent epileptic seizure or other paroxysmal event (psychogenic). (C) 2011 Elsevier Inc. All rights reserved.