Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.
Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.
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DOI：
10.4049/jimmunol.155.8.3711
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发表时间：
1995-10
影响因子：
4.4
通讯作者：
K. Hiyama;Y. Hirai;S. Kyoizumi;M. Akiyama;E. Hiyama;Mieczyslaw A. Piatyszek;J. Shay;S. Ishioka;M. Yamakido
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文献类型：
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作者：
K. Hiyama;Y. Hirai;S. Kyoizumi;M. Akiyama;E. Hiyama;Mieczyslaw A. Piatyszek;J. Shay;S. Ishioka;M. Yamakido
这是第一个描述人类正常细胞端粒酶活性上调的报告。端粒酶是一种核糖核蛋白酶，被认为参与维持种系细胞和大多数癌细胞端粒长度的稳定性，但在正常细胞中没有。然而，在目前的研究中，我们证明端粒酶活性在正常的人T细胞和B细胞中检测到低水平，在体外有丝分裂刺激下增加，在造血祖细胞增殖和分化时增加，并随着年龄的增长而降低。了解正常细胞中端粒酶活性的调节不仅可以为正常细胞衰老的机制提供重要的见解，还可以为端粒酶活性失调作为癌症发展的一部分的机制提供重要的见解。
This is the first report describing up-regulation of telomerase activity in human normal cells. Telomerase, a ribonucleoprotein enzyme, has been thought to be involved in maintaining telomere length stability in germline and most cancer cells, but not in normal cells. However, in the present study, we demonstrate that telomerase activity is detectable at low levels in normal human T and B cells, increases by in vitro mitogenic stimulation, increases in hematopoietic progenitor cells upon their proliferation and differentiation, and decreases with aging. Understanding the regulation of telomerase activity in normal cells may provide important insights not only into the mechanisms of normal cellular senescence but also into the mechanisms of telomerase activity deregulation as part of cancer development.