ZNF750 Expression as a Novel Candidate Biomarker of Chemoradiosensitivity in Esophageal Squamous Cell Carcinoma
ZNF750 Expression as a Novel Candidate Biomarker of Chemoradiosensitivity in Esophageal Squamous Cell Carcinoma
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DOI：
10.1159/000476068
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发表时间：
2017-01-01
期刊：
影响因子：
3.5
通讯作者：
Matsubara, Hisahiro
中科院分区：
文献类型：
--
作者：
Otsuka, Ryota;Akutsu, Yasunori;Matsubara, Hisahiro
目的：ZNF 750是一种表皮分化调节因子，被认为是食管鳞状细胞癌（ESCC）的抑癌因子。虽然表皮分化基因和放化疗（CRT）的抵抗之间的相关性已被假定，没有数据关于ZNF 750的状态在ESCC已被报道。本研究的目的是评估ZNF 750表达与食管鳞癌CRT疗效的关系。方法：对87例经病理证实的食管鳞癌患者进行分析。所有患者均接受了新辅助CRT，随后进行了根治性食管切除术。ZNF 750在预处理活检样品中的表达进行了免疫化学研究，并与CRT在手术标本中的组织病理学效果进行了比较。结果：ZNF 750高表达与CRT敏感性密切相关（p = 0.016）。单变量分析显示，ZNF 750的高/中表达是CRT敏感性良好的显著预测因素（p = 0.006）。在多变量分析中，ZNF 750的高/中等表达（30%或以上）仍然是CRT敏感性的独立预测因素（p = 0.033）。结论：ZNF 750表达可预测食管鳞癌对CRT的敏感性，并可作为预测食管鳞癌对CRT反应的可靠生物标志物。(C)2017 S. Karger AG，巴塞尔
Objective: ZNF750, an epidermal differentiation regulator, has been suggested to act as a tumor suppressor of esophageal squamous cell carcinoma (ESCC). Although a correlation between the epidermal differentiation gene and resistance to chemoradiotherapy (CRT) has been posited, no data regarding the ZNF750 status in ESCC have been reported. The aim of the present study was to evaluate the relationship between ZNF750 expression and response to CRT in ESCC. Methods: Eighty-seven patients who had been pathologically diagnosed with ESCC were evaluated in the present study. All patients underwent neoadjuvant CRT, followed by curative esophagectomy. The expression of ZNF750 in pretreatment biopsy samples was immunohistochemically investigated and compared to the histopathological effectiveness of CRT in surgical specimens. Results: High expression of ZNF750 was closely correlated with good sensitivity to CRT (p = 0.016). A univariate analysis showed that high/inter-mediate expression of ZNF750 was a significant predictive factor for good sensitivity to CRT (p = 0.006). High/inter-mediate expression of ZNF750 (30% or more) remained an independent predictive factor for sensitivity to CRT in a multivariate analysis (p = 0.033). Conclusions: ZNF750 expression predicts sensitivity to CRT and can be a biomarker that reliably predicts the response of ESCC to CRT. (C) 2017 S. Karger AG, Basel