CEREBRAL BLOOD-FLOW AND CO-2 RESPONSIVENESS AS AN INDICATOR OF COLLATERAL RESERVE CAPACITY IN PATIENTS WITH CAROTID ARTERIAL-DISEASE
CEREBRAL BLOOD-FLOW AND CO-2 RESPONSIVENESS AS AN INDICATOR OF COLLATERAL RESERVE CAPACITY IN PATIENTS WITH CAROTID ARTERIAL-DISEASE
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DOI：
10.1002/bjs.1800720506
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发表时间：
1985-01-01
影响因子：
9.6
通讯作者：
ALLARDICE, G
中科院分区：
文献类型：
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作者：
BULLOCK, R;MENDELOW, AD;ALLARDICE, G
在74例有脑血管疾病症状的患者中测量了静息脑血流量（CBF）和吸入7%二氧化碳的反应。为了评估它们在鉴别有重大动脉病变患者中的作用，我们将这些测量结果与血管造影表现、临床表现以及CT扫描上是否存在梗死相关联。颈动脉狭窄60%或以上的患者静息血流正常，但对二氧化碳吸入的反应性降低。颈动脉闭塞患者的静息血流和二氧化碳反应性均降低。25%的大脑半球可见梗死，在固定神经功能缺损的患者中更常见，但也存在于17%的短暂性缺血发作（tia）患者中。经威利斯环的对侧颈动脉侧支供应减少进一步降低同侧颈内动脉闭塞患者的co2反应性。随着二氧化碳的吸入而发生的CBF的正常增加随着日益严重的双侧疾病、梗死和固定的神经功能缺陷而减少。
Resting cerebral blood flow (CBF) and the response to inhalation of 7 per cent CO2was measured in 74 patients with symptoms of cerebrovascular disease. In order to evaluate their role in the identification of patients with significant arterial lesions, these measurements were correlated with the angiographic appearances, the clinical picture and the presence or absence of infarction on CT scan. Patients with carotid stenosis of 60 per cent or more had normal resting flows, but reduced responsiveness to CO2inhalation. Patients with carotid occlusion had both reduced resting flow and reduced CO2responsiveness. Infarcts were visible in 25 per cent of the hemispheres studied, and were more common in patients with fixed neurological deficits, but were also present in 17 per cent of patients with transient ischaemic attacks (TIAs). Reduction in the collateral supply from the contralateral carotid artery via the Circle of Willis further reduced CO2responsiveness with ipsilateral internal carotid occlusion. The normal increase in CBF which occurs with the inhalation of carbon dioxide is diminished with increasingly severe bilateral disease, with infarction and with a fixed neurological deficit.