The possible role of hepatitis A virus in the pathogenesis of atherosclerosis.
The possible role of hepatitis A virus in the pathogenesis of atherosclerosis.
复制标题
甲型肝炎病毒在动脉粥样硬化发病机制中的可能作用。
DOI：
10.1086/317613
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Epstein,SE
中科院分区：
文献类型：
--
作者：
Zhu,J;Quyyumi,AA;Norman,JE;Costello,R;Csako,G;Epstein,SE
目的探讨甲型肝炎病毒（HAV）感染与冠心病（CAD）的关系。对391例接受冠状动脉造影的患者进行了血清甲型肝炎病毒（HAV）IgG抗体和C反应蛋白（CRP）检测。在391例患者中，205例（52%）有抗HAV IgG抗体。HAV血清阳性患者的CAD患病率为74%，HAV血清阴性患者的CAD患病率为52%（P< .0001）;调整传统CAD危险因素或危险因素加其他感染因子（巨细胞病毒、肺炎衣原体、幽门螺杆菌和单纯疱疹病毒）后，显著性持续存在。此外，在单变量和多变量分析中，HAV血清阳性患者的CRP水平显著高于HAV血清阴性患者（P= 0.013）。逻辑回归分析表明，HAV血清阳性是CAD和CRP水平升高风险的独立预测因素。因此，HAV感染与CAD相关，这增加了该病毒可能在动脉粥样硬化形成中起因果作用的可能性。
The possible association between hepatitis A virus (HAV) infection and coronary artery disease (CAD) was studied. Blood from 391 patients undergoing coronary angiography was tested for serum IgG antibodies to HAV and C-reactive protein (CRP). Of the 391 patients, 205 (52%) had anti-HAV IgG antibodies. CAD prevalence was 74% in HAV-seropositive and 52% in HAV-seronegative patients (P< .0001); significance persisted after adjustment for either traditional CAD risk factors or for risk factors plus other infectious agents (cytomegalovirus,Chlamydia pneumoniae, Helicobacterpylori, and herpes simplex virus). In addition, CRP levels were significantly higher in HAV-seropositive than in HAV-seronegative patients (P= .013) in both univariate and multivariate analyses. Logistic regression analysis demonstrated that HAV seropositivity is an independent predictor of risk for CAD and elevated CRP levels. HAV infection is therefore associated with CAD, which raises the possibility that this virus may play a causal role in atherogenesis.