A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon alpha.
A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon alpha.
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使用肌肉注射编码干扰素 α 的质粒 DNA 来治疗癌症的基因疗法。
DOI：
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发表时间：
1999
影响因子：
11.1
通讯作者：
S. Parker
中科院分区：
文献类型：
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作者：
H. Horton;D. Anderson;P. Hernández;K. Barnhart;J. Norman;S. Parker
描述了一种癌症治疗方法，在该方法中，I.M.注射编码小鼠干扰素α的质粒DNA(PDNA)对小鼠的原发瘤和转移性肿瘤有很强的抗肿瘤作用。携带SC的小鼠。肌肉注射B16F10黑色素瘤、Cloudman黑色素瘤、胶质瘤261个肿瘤。携带m干扰素-αpDNA。在所有三种肿瘤模型中，均发现干扰素PDNA治疗后肿瘤体积显著缩小，生存期显著提高。M干扰素-αpDNA注射的频率可以与每隔一周注射一次一样少，但仍能产生显著的抗肿瘤效果，并且在转移肿瘤模型中，该疗法显著减少了肺肿瘤转移的数量。免疫细胞亚群的耗尽表明CD8(+)T细胞是抗肿瘤反应所必需的。这些研究表明，原发性和转移性肿瘤可以通过肌肉注射进行系统治疗。注射编码细胞因子基因的质粒组。
A cancer treatment is described in which i.m. injection of plasmid DNA (pDNA) encoding murine interferon alpha (mIFN-alpha) leads to potent antitumor effects on primary and metastatic tumors in mice. Mice bearing s.c. B16F10 melanoma, Cloudman melanoma, or glioma 261 tumors were injected i.m. with mIFN-alpha pDNA. In all three tumor models, a significant reduction in tumor volume and enhancement of survival was found after IFN pDNA therapy. The mIFN-alpha pDNA could be injected as infrequently as once every other week and still produce a significant antitumor effect, and, in a metastatic tumor model, the therapy markedly reduced the number of lung tumor metastases. Depletion of immune cell subsets indicated that CD8(+) T cells were required for the antitumor response. These studies demonstrate that primary and metastatic tumors can be treated systemically by i.m. injection of a plasmid encoding a cytokine gene.
影响因子：
11.2
作者：
L. Pfeffer;C. Dinarello;R. Herberman;B. Williams;E. Borden;R. Bordens;M. Walter;T. L. Nagabhushan;P. Trotta;S. Pestka
通讯作者：
L. Pfeffer;C. Dinarello;R. Herberman;B. Williams;E. Borden;R. Bordens;M. Walter;T. L. Nagabhushan;P. Trotta;S. Pestka
注射到骨骼肌中的细胞因子基因的全身免疫效应。
DOI：
10.1073/pnas.90.10.4523
发表时间：
1993
影响因子：
11.1
作者：
Raz,E;Watanabe,A;Baird,SM;Eisenberg,RA;Parr,TB;Lotz,M;Kipps,TJ;Carson,DA
通讯作者：
Carson,DA
硼中子捕获疗法治疗小鼠恶性胶质瘤。
影响因子：
11.2
作者：
Saris,SC;Solares,GR;Wazer,DE;Cano,G;Kerley,SE;Joyce,MA;Adelman,LS;Harling,OK;Madoc-Jones,H;Zamenhof,RG
通讯作者：
Zamenhof,RG