CALCIFICATION IN HUMAN BREAST CARCINOMAS - ULTRASTRUCTURAL OBSERVATIONS
CALCIFICATION IN HUMAN BREAST CARCINOMAS - ULTRASTRUCTURAL OBSERVATIONS
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DOI：
10.1002/path.1711170407
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发表时间：
1975-01-01
影响因子：
7.3
通讯作者：
AHMED, A
中科院分区：
文献类型：
--
作者：
AHMED, A
人类乳腺癌的钙化已通过超微结构进行了研究。在肿瘤细胞中观察到与电子致密材料密切相关的针状晶体的多个沉积物。类似的沉积物存在于胞质内腔和邻近的基质中。在膜结合的囊泡和部分膜结合的晶体簇中观察到细胞质钙化。这表明钙化是活跃分泌过程的结果，而不是钙化坏死或退化的肿瘤细胞的结果。讨论了钙化的可能机制。电子衍射和电子探针分析均表明该晶体材料为羟基磷灰石。
Calcification in human breast carcinomas has been studied ultrastructurally. Multiple deposits of needle-shaped crystals intimately associated with electrondense material were observed among tumour cells. Similar deposits were present in intracytoplasmic lumina and the adjacent stroma. Cytoplasmic calcification was seen in membrane-bound vesicles and as partially membrane-bound clusters of crystals. It is suggested that the calcification is the result of an active secretory process rather than calcified necrotic or degenerate tumour cells. The possible mechanisms of calcification are discussed. Both electron diffraction and electron probe analysis show that the crystaline material is hydroxyapatite.