A NOVEL PHENOLIC GLYCOLIPID FROM MYCOBACTERIUM-LEPRAE POSSIBLY INVOLVED IN IMMUNOGENICITY AND PATHOGENICITY
A NOVEL PHENOLIC GLYCOLIPID FROM MYCOBACTERIUM-LEPRAE POSSIBLY INVOLVED IN IMMUNOGENICITY AND PATHOGENICITY
复制标题
DOI：
10.1128/jb.147.3.728-735.1981
复制
发表时间：
1981-01-01
影响因子：
3.2
通讯作者：
BRENNAN, PJ
中科院分区：
文献类型：
--
作者：
HUNTER, SW;BRENNAN, PJ
从M.从受感染的犰狳肝脏中分离出的麻风病。红外光谱和核磁共振谱表明该化合物与M. Kansai，因此是糖基酚邻苯二甲酸二酯。两种产品之间的关键差异在于连接的三糖的组成。GLC-质谱分析表明，M. kansasii的单糖主要由2，4-二-O-甲基鼠李糖、2-O-甲基鼠李糖和2-O-甲基岩藻糖组成;麻风含有2，3-二-O-甲基鼠李糖、3-O-甲基鼠李糖和3，6-二-O-甲基葡萄糖。糖脂的寡糖片段的独特组成从M。麻风可能使其有助于从化学和血清学上将该生物体与其他分枝杆菌区分开。令人惊讶的是，在不含M的感染肝残留物中也发现大量（2.2 mg/g干肝）糖脂。麻风，这表明它可能是负责电子透明泡沫周围的有机体在感染的麻风瘤组织。
A phenolic glycolipid was obtained in high amounts (2% of dry wt) from M. leprae isolated from infected armadillo liver. IR and NMR spectroscopy showed that it is closely related to mycoside A from M. kansaii and is therefore a glycosylphenolic phthiocerol diester. The crucial difference between the 2 products is in the composition of the attached trisaccharide. GLC-mass spectroscopy showed that the product from M. kansasii is composed of 2,4-di-O-methylrhamnose, 2-O-methylrhamnose and 2-O-methylfucose, whereas that from M. leprae contains 2,3-di-O-methylrhamnose, 3-O-methylrhamnose and 3,6-di-O-methylglucose. The distinct composition of the oligosaccharide segment of the glycolipid from M. leprae may make it useful for the chemical and serological differentiation of this organism from other mycobacteria. Surprisingly large quantities (2.2 mg/g of dry liver) of the glycolipid were also found in infected liver residue freed of M. leprae, suggesting that it may be responsible for the electron-transparent foam surrounding the organism in infected lepromatous tissue.