Stem cells in the umbilical cord
Stem cells in the umbilical cord
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DOI：
10.1007/s12015-006-0022-y
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发表时间：
2006-06-01
期刊：
影响因子：
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通讯作者：
Troyer, Deryl L.
中科院分区：
文献类型：
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作者：
Weiss, Mark L.;Troyer, Deryl L.
干细胞是医学的下一个前沿。干细胞被认为具有巨大的治疗和生物技术潜力。这不仅可以替换受损或功能失调的细胞，还可以拯救它们和/或在它们被工程化后提供治疗性蛋白质。目前，胚胎干细胞和胎儿干细胞都存在伦理和科学问题，阻碍了它们的广泛应用。相比之下，出生后从脐带回收的干细胞，包括脐带血细胞、羊膜/胎盘、脐带静脉或脐带基质细胞，是能够形成许多不同细胞类型（即，它们是“多能的”）。本文就脐带来源的干细胞及其与成人骨髓间充质干细胞的比较作一综述。
Stem cells are the next frontier in medicine. Stem cells are thought to have great therapeutic and biotechnological potential. This will not only to replace damaged or dysfunctional cells, but also rescue them and/or deliver therapeutic proteins after they have been engineered to do so. Currently, ethical and scientific issues surround both embryonic and fetal stem cells and hinder their widespread implementation. In contrast, stem cells recovered postnatally from the umbilical cord, including the umbilical cord blood cells, amnion/placenta, umbilical cord vein, or umbilical cord matrix cells, are a readily available and inexpensive source of cells that are capable of forming many different cell types (i.e., they are "multipotent"). This review will focus on the umbilical cord-derived stem cells and compare those cells with adult bone marrow-derived mesenchymal stem cells.