Apolipoprotein E, amyloid, and Alzheimer disease.
Apolipoprotein E, amyloid, and Alzheimer disease.
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DOI：
10.1124/mi.2.6.363
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发表时间：
2002-10-01
影响因子：
--
通讯作者：
Paul, S M
中科院分区：
文献类型：
--
作者：
Bales, K R;Dodart, J C;Paul, S M
尽管阿尔茨海默病的分子病理学取得了重要进展，但对这种疾病的有效长期治疗仍然难以捉摸。在许多被认为是疾病因素的基因产物中，有一种是载脂蛋白(ApoE)。载脂蛋白E的特定亚型对阿尔茨海默病的风险显然各不相同，因此载脂蛋白E在大脑中扮演的角色对于充分了解疾病和努力开发有效的治疗方法至关重要。
Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein ( (apoE). The risk that specific isoforms of apoE pose with regard to Alzheimer Disease clearly varies, and so the roles that apoE plays in the brain will be crucial to a full understanding of the disease and to efforts to develop effective therapies.