NITROGEN-OXIDE LEVELS IN PATIENTS AFTER TRAUMA AND DURING SEPSIS
NITROGEN-OXIDE LEVELS IN PATIENTS AFTER TRAUMA AND DURING SEPSIS
复制标题
DOI：
10.1097/00000658-199111000-00013
复制
发表时间：
1991-11-01
影响因子：
9
通讯作者：
PEITZMAN, AB
中科院分区：
文献类型：
--
作者：
OCHOA, JB;UDEKWU, AO;PEITZMAN, AB
在脓毒症中观察到的负责维持高动力状态和低全身血管阻力（SVR）的介质尚未阐明。一氧化氮（。N = O）是一种具有多种功能的介质，包括调节血管张力以及在巨噬细胞介导的细胞抑制和微生物抑制中发挥作用。研究了39例重症创伤和脓毒症患者，以确定两者之间的关系。N = O生产和超动力状态。高血浆水平的NO2-/NO3-（稳定的最终产物。N = 0）（p < 0.02）。低SVR和高内毒素水平与高NO2 /NO3值相关（p = 0.029，p = 0.002）。N = O水平的变化可能介导脓毒症中观察到的血管舒张。在创伤患者中观察到低NO2-/NO3-水平（p < 0.001），并且即使在存在脓毒症的情况下也保持低水平（p = 0.001）。
The mediators responsible for maintenance of the hyperdynamic state and the low systemic vascular resistance (SVR) observed in sepsis have not been elucidated. Nitric oxide (. N = O) is a mediator with numerous functions, including regulation of vascular tone and a role in macrophage-mediated cytostasis and microbiostasis. Thirty-nine critically ill trauma and septic patients were studied to determine the relationship between . N = O production and the hyperdynamic state. High plasma levels of NO2-/NO3- (the stable end products of . N = O) were observed in septic patients (p < 0.02). Low SVR and high endotoxin levels were associated with high NO2 /NO3- values (p = 0.029, p = 0.002). Changes in .N = O levels may mediate the vasodilation seen in sepsis. Low NO2-/NO3- levels were observed in trauma patients (p < 0.001) and remained low even in the presence of sepsis (p = 0.001).