Parasite potpourri: Toxoplasma gondii lineage tracing in vivo.

Parasite potpourri: Toxoplasma gondii lineage tracing in vivo.
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寄生虫百花香:体内弓形虫谱系追踪。

DOI:
10.1016/j.pt.2022.10.002
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发表时间:
2022
影响因子:
9.6
通讯作者:
Koshy,AnitaA
Koshy,AnitaA
中科院分区:
医学1区
文献类型:
--
作者:
Koshy,AnitaA

文献摘要

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使用基于CRISPR/Cas9的方法,Wincott等人产生了由96个条形码克隆谱系组成的稳定,复杂的弓形虫种群。通过跟踪体内的群体结构,他们确定了-与预期相反-感染大脑的途径对T广泛开放。刚地。
Using a CRISPR/Cas9-based method, Wincott et al. generated a stable, complexToxoplasma gondiipopulation composed of 96 barcoded clonal lineages. By tracking the population structurein vivo, they determine that – contrary to expectations – the pathway to infecting the brain is widely permissive forT. gondii.