Spectrally dependent roll-off in visible-light optical coherence tomography.
Spectrally dependent roll-off in visible-light optical coherence tomography.
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DOI：
10.1364/ol.389240
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发表时间：
2020-05-01
期刊：
影响因子：
3.6
通讯作者：
Zhang HF
中科院分区：
文献类型：
--
作者：
Rubinoff I;Soetikno B;Miller DA;Rischall I;Fawzi A;Kuranov R;Zhang HF
可见光光学相干层析成像（vis-OCT）的最新发展为无创光谱成像引入了新的应用。然而，测量光谱可能会被频谱相关滚降（SDR）所改变。我们制定了SDR的数学模型，该模型考虑了光谱仪中的非均匀波数间隔、光学像差和失调。我们基于该模型模拟了SDR，并发现与vis-OCT系统的测量结果非常吻合。我们证实SDR改变了全氧血的光谱测量。我们通过用光谱仪测量的SDR将每个光谱相关的a线归一化来纠正这些变化。我们的研究开发并验证了SDR的定量描述，这对OCT光谱仪的设计、对准和光谱测量至关重要。
Recent development of visible-light optical coherence tomography (vis-OCT) has introduced new applications for noninvasive spectroscopic imaging. However, the measured spectra may be altered by spectrally dependent roll-off (SDR). We formulated a mathematical model for SDR that accounted for nonuniform wavenumber spacing, optical aberrations, and misalignments in the spectrometer. We simulated SDR based on this model and found strong agreement with measurements from a vis-OCT system. We verified that SDR altered spectroscopic measurements of fully oxygenated blood. We corrected these alterations by normalizing each spectrally dependent A-line by the measured SDR of the spectrometer. Our investigations develop and verify a quantitative description of SDR critical for informing OCT spectrometer design, alignment, and spectroscopic measurements.