Transcriptional and Post-Transcriptional Regulation of Autophagy.
Transcriptional and Post-Transcriptional Regulation of Autophagy.
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作者：
Ma Q;Long S;Gan Z;Tettamanti G;Li K;Tian L
自噬是真核生物中广泛存在的一个保守过程，它参与了一系列生理和病理事件，包括发育、免疫、神经退行性疾病和肿瘤发生。它通过多种途径受到营养缺乏、能量应激和其他不利条件的调节。一般来说，自噬在RNA和蛋白质水平上协同控制。上游转录因子触发或抑制自噬或溶酶体相关基因的表达以促进或减少自噬。此外，据报道，大量非编码RNA（microRNA、circRNA和lncRNA）参与自噬调节。最后，转录后修饰，如RNA甲基化，在控制自噬发生中起关键作用。本文综述了自噬在转录调控方面的研究进展，为自噬机制的进一步研究提供了基础和方向。
Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. In general, autophagy is synergistically governed at the RNA and protein levels. The upstream transcription factors trigger or inhibit the expression of autophagy- or lysosome-related genes to facilitate or reduce autophagy. Moreover, a significant number of non-coding RNAs (microRNA, circRNA, and lncRNA) are reported to participate in autophagy regulation. Finally, post-transcriptional modifications, such as RNA methylation, play a key role in controlling autophagy occurrence. In this review, we summarize the progress on autophagy research regarding transcriptional regulation, which will provide the foundations and directions for future studies on this self-eating process.
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