The role of prostaglandins in mediating the effects of angiotensin converting enzyme inhibitors and other antihypertensive drugs.
The role of prostaglandins in mediating the effects of angiotensin converting enzyme inhibitors and other antihypertensive drugs.
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前列腺素在介导血管紧张素转换酶抑制剂和其他抗高血压药物的作用中的作用。
DOI：
10.1007/bf02125831
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发表时间：
1987
影响因子：
3.4
通讯作者：
Swartz,SL
中科院分区：
文献类型：
--
作者：
Swartz,SL
本文认为血管紧张素转换酶（ACE）抑制剂和其他降压药物可能通过改变血管收缩和血管扩张激素的平衡来降低血压。大多数原发性高血压的特点是血管阻力增加。由于血管阻力可以被视为抵消血管收缩剂和血管舒张剂神经体液力的净平衡，并且由于血管紧张素II和去甲肾上腺素可以刺激血管舒张剂前列腺素的合成，从而抵消周围血管收缩，因此我们测量了在给予不同的降压药物后血管收缩剂（血管紧张素II）和血管舒张剂（PGE2）激素的变化。我们发现巯基转化酶抑制剂卡托普利可急性和慢性地增加血管舒张剂前列腺素的生成（pge2代谢物）。这种pge2代谢物的增加在非巯基转化酶抑制剂依那普利中没有看到。
This review considers the hypothesis that angiotensin converting enzyme (ACE) inhibitors and other antihypertensive drugs may reduce blood pressure by altering the balance of vasoconstrictor and vasodilator hormones. Most cases of essential hypertension are characterized by increased vascular resistance. Since vascular resistance can be viewed as a net balance of offsetting vasoconstrictor and vasodilator neurohumoral forces, and since angiotensin II and norepinephrine can stimulate the synthesis of vasodilator prostaglandins that can in turn counteract peripheral vasoconstriction, we measured changes in vasoconstrictor (angiotensin II) and vasodilator (PGE2) hormones after giving different antihypertensive drugs. We found that the sulfhydryl containing converting enzyme inhibitor captopril increased vasodilator prostaglandin production (PGE2-metabolite) both acutely and chronically. This increase in PGE2-metabolite was not seen with the non-sulfhydryl converting enzyme inhibitor, enalapril.