Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart.
Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart.
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DOI：
10.14336/ad.2023.0205
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发表时间：
2023-10-01
影响因子：
7.4
通讯作者：
Lesnefsky, Edward J.
中科院分区：
文献类型：
--
作者：
Bates, Lauryn;Krause-Hauch, Meredith;Wang, Hao;Fatmi, Mohammad Kasim;Li, Zehui;Chen, Qun;Ren, Di;Li, Ji;Lesnefsky, Edward J.
关键词：
尽管进行了成功的再灌注治疗，老年患者（年龄 > 75 岁）仍会出现更大的梗塞，ST段抬高型心肌梗塞（STEMI）的死亡率更高。尽管对临床和血管造影变量进行了校正，但老年年龄仍然是一个独立的风险。老年人是高危人群，除了单独再灌注之外，还可能受益于治疗。我们假设，在再灌注时给予急性高剂量二甲双胍来调节心脏信号传导和代谢，将表现出额外的心脏保护作用。使用体内 STEMI 的转化衰老小鼠模型（22-24 个月的 C57BL/6J 小鼠）（动脉闭塞 45 分钟，再灌注 24 小时）；再灌注时用高剂量二甲双胍进行急性治疗可减少梗塞面积并增强收缩恢复，证明对高危衰老心脏具有心脏保护作用。
Elderly patients (age > 75) sustain larger infarcts with greater mortality from ST elevation myocardial infarcts (STEMI) despite successful reperfusion treatment. Elderly age remains an independent risk despite correction for clinical and angiographic variables. The elderly represent a high-risk population and may benefit from treatment in addition to reperfusion alone. We hypothesized that modulation of cardiac signaling and metabolism with acute, high dose metformin given at reperfusion would exhibit additional cardioprotection. Using a translational aging murine model (22-24-month C57BL/6J mice) of in vivo STEMI (45 min artery occlusion with reperfusion for 24 hours); treatment acutely at reperfusion by high dose metformin decreased infarct size and enhanced contractile recovery, demonstrating cardioprotection in the high-risk aging heart.