Regulatory B cells promote graft-versus-host disease prevention and maintain graft-versus-leukemia activity following allogeneic bone marrow transplantation
Regulatory B cells promote graft-versus-host disease prevention and maintain graft-versus-leukemia activity following allogeneic bone marrow transplantation
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调节性 B 细胞促进移植物抗宿主病预防并维持同种异体骨髓移植后的移植物抗白血病活性
DOI：
10.1080/2162402x.2017.1284721
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发表时间：
2017-01-01
期刊：
影响因子：
7.2
通讯作者：
Huang, Xiao-Jun
中科院分区：
文献类型：
--
作者：
Hu, Yue;He, Gan-Lin;Huang, Xiao-Jun
摘要调节性B细胞参与移植物抗宿主病(GVHD)的发病过程。然而，Bregs能否在不影响移植物抗白血病(GVL)效应的情况下缓解急性GVHD仍不清楚。在这里，我们在小鼠模型和临床队列研究中评估了Bregs在急性GVHD和GVL活动中的作用。在急性GVHD小鼠模型中，Bregs共移植通过抑制Th1和Th17分化和扩大调节性T细胞来预防发病。在GVL小鼠模型中，Bregs有助于抑制急性GVHD，但对GVL活性没有不良影响。在临床队列研究中，移植肾中Bregs剂量越高，急性移植物抗宿主病的累积发生率越低，但与复发风险增加无关。我们的数据表明，Bregs可以预防急性GVHD并维持GVL效应，并提示Bregs具有作为缓解急性GVHD的新策略的潜力。
ABSTRACT Regulatory B cells (Bregs) are involved in the pathogenesis of graft-versus-host disease (GVHD). However, whether Bregs can alleviate acute GVHD without compromising graft-versus-leukemia (GVL) effects remains unclear. Here, we evaluated the role of Bregs in acute GVHD and GVL activity in both a mouse model and a clinical cohort study. In the acute GVHD mouse model, co-transplantation of Bregs prevents onset through inhibiting Th1 and Th17 differentiation and expanding regulatory T cells. In the GVL mouse model, Bregs contributed to the suppression of acute GVHD but had no adverse effect on GVL activity. In the clinical cohort study, a higher dose of Bregs in allografts was associated with a lower cumulative incidence of acute GVHD but not with increased risk of relapse. Our data demonstrate that Bregs can prevent acute GVHD and maintain GVL effects and suggest that Bregs have potential as a novel strategy for acute GVHD alleviation.