Acinar cell basal-lateral membrane-endomembrane traffic may mediate interactions with both T cells and B cells.
Acinar cell basal-lateral membrane-endomembrane traffic may mediate interactions with both T cells and B cells.
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腺泡细胞基底-侧膜-内膜交通可能介导与 T 细胞和 B 细胞的相互作用。
DOI：
10.1007/978-1-4615-5359-5_6
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发表时间：
1998
影响因子：
--
通讯作者：
Wood,RL
中科院分区：
文献类型：
--
作者：
Mircheff,AK;Yang,T;Zhang,J;Zeng,H;Gierow,JP;Warren,DW;Wood,RL
泪腺通常由大量产生IgA的浆细胞和T淋巴细胞组成，其中CD8细胞是CD4细胞的两倍。这些细胞的数量在正常衰老过程中增加，并且有人推测它们可能会加剧原发性泪液缺乏的泪液功能障碍。淋巴细胞浸润在干燥综合征中显著增加，干燥综合征是一种免疫系统疾病，其中CD 4细胞占T淋巴细胞群的主导地位，抗体产生群包括大量B细胞。B细胞浸润是多克隆的，并且通常产生针对细胞内抗原的IgG和IgM，所述细胞内抗原例如核糖核蛋白Ro和La以及多种高尔基体蛋白。由于眼表疾病的严重性以及干燥综合征全身表现的衰弱和潜在危及生命的性质，确定导致泪腺中CD 4细胞和B细胞增殖的机制非常重要。
The lacrimal glands are normally populated by significant numbers of IgA-producing plasma cells and T lymphocytes, with CD8 cells in twofold excess over CD4 cells. The numbers of these cells increase during normal aging, and there has been speculation that they may exacerbate the lacrimal dysfunction of primary lacrimal deficiency. Lymphocytic infiltration increases much more dramatically in Sjögren’s syndrome, an immune system disorder in which CD4 cells dominate the T lymphocyte population, and the antibody-producing population includes large numbers of B cells. The B cell infiltrates are polyclonal and often produce IgG and IgM against intracellular antigens, such as the ribonuclear proteins Ro and La and a variety of Golgi proteins. Because of the severity of the ocular surface disease and the debilitating and potentially life-threatening nature of the systemic manifestations of Sjögren’s syndrome, it is important to identify the mechanisms that lead to CD4 cell and B cell proliferation in the lacrimal glands.