Diet, growth, and the risk for type 1 diabetes in childhood -: A matched case-referent study
Diet, growth, and the risk for type 1 diabetes in childhood -: A matched case-referent study
复制标题
DOI：
10.2337/diacare.27.12.2784
复制
发表时间：
2004-12-01
期刊：
影响因子：
16.2
通讯作者：
Dahlquist, G
中科院分区：
文献类型：
--
作者：
Pundziute-Lyckå, A;Persson, LÅ;Dahlquist, G
目的-研究1型糖尿病风险和以前摄入的能量之间的关联，占身体大小和以前摄入的营养素和食物，占energyintake.RESEARCH设计和方法-我们进行了一项事件人口为基础的病例-参照研究在斯德哥尔摩，瑞典，包括99 100合格的7- 14岁的糖尿病儿童和180 200岁，通过瑞典人口登记确定的性别和地区匹配的参照儿童。在糖尿病诊断/访谈前一年，使用食物频率问卷评估消耗的食物量，估计平均每日能量和营养素摄入量。使用诊断前最后4年内进行的生长测量的平均SD评分。通过条件逻辑回归计算比值比（OR）。结果-病例受试者的能量、碳水化合物、脂肪和蛋白质的平均摄入量以及平均年龄别体重SD评分均显着较高。在相互调整后，较高的能量摄入和年龄别体重都与糖尿病风险增加相关：中、高能量摄入的OR（95%CI）分别为1.33年龄别体重分别为3.20（1.30-7.88）和3.09（1.16-8.22）。高碳水化合物的摄入，特别是二糖和蔗糖，增加糖尿病的风险。结论-更高的能量摄入和更大的体型与糖尿病风险增加独立相关。在不同的营养素中，碳水化合物，特别是二糖和蔗糖的摄入量增加了风险。导致儿童期能量摄入量增加和生长速度加快的生活方式习惯可能通过不同的机制导致儿童期发病的I型糖尿病增加。
OBJECTIVE - To study the association between type 1 diabetes risk and previous intake of energy, accounting for body size and previous intake of nutrients and foods, accounting for the energy intake.RESEARCH DESIGN AND METHODS - We conducted an incident population-based case-referent study in Stockholm, Sweden, including 99 of 100 eligible 7- to 14-year-old diabetic children and 180 of 200 age-, sex-, and area-matched referent children identified through the Swedish population register. Average daily energy and nutrient intake I year before diabetes diagnosis/interview was estimated using the food frequency questionnaire with assessment of consumed food amounts. Mean SD scores of growth measurements taken during the last 4 years before the diagnosis were used. Odds ratios (ORs) were calculated by conditional logistic regression.RESULTS - Average intake of energy, carbohydrate, fat, and protein was significantly higher among the case subjects as well as mean weight-for-age SD score. Higher energy intake and weight-for-age were both associated with increased diabetes risk after adjustment for each other: OR (95% CI) for medium and high levels of energy intake were 1.33 (0.52-3.42) and 5.23 (1.67-16.38), respectively, and for weight-for-age were 3.20 (1.30-7.88) and 3.09 (1.16-8.22), respectively. High intake of carbohydrates, especially disaccharides and sucrose, increased diabetes risk.CONCLUSIONS - Higher energy intake and larger body size were independently associated with increased diabetes risk. Of the different nutrients, higher intake of carbohydrates, particularly disaccharides and sucrose, increased the risk. Lifestyle habits leading to higher energy intake and more rapid growth in childhood may contribute to the increase of childhood-onset type I diabetes by different mechanisms.