CALL FOR PAPERS Innovative and Emerging Technologies in GI Physiology and Disease Water-perfused esophageal high-resolution manometry: normal values and validation
CALL FOR PAPERS Innovative and Emerging Technologies in GI Physiology and Disease Water-perfused esophageal high-resolution manometry: normal values and validation
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征文 胃肠道生理学和疾病中的创新和新兴技术 水灌注食管高分辨率测压法：正常值和验证
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
A. Bredenoord
中科院分区：
文献类型：
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作者：
B. Kessing;P. W. Weijenborg;A. Smout;Sem Hillenius;A. Bredenoord
Kessing BF，Weijenborg PW，Smout AJ，Hillenius S，Bredenoord AJ.水灌注食管高分辨率测压;正常值和验证。美国生理学杂志胃肠和肝脏生理学306：G491-G495，2014年。首次发表于2014年1月30日; doi：10.1152/ajpgi.00447.2013.-最近开发了具有36个单向压力通道的水灌注高分辨率测压（HRM）导管，但尚未获得正常值。此外，该技术尚未得到验证，并与固态HRM进行比较。因此，我们的目的是开发水灌注HRM的正常值，并评估水灌注HRM和固态HRM之间的协议水平。我们纳入了50名健康志愿者（平均年龄35岁，范围21-64岁; 15名女性，35名男性）。以随机顺序进行水灌注HRM和固态HRM。正常值计算为第5百分位数和第95百分位数范围，两个系统之间的一致性采用组内相关系数（ICC）统计进行评估。第5 - 95百分位数范围为：收缩前速度（CFV）3.0-6.6 cm/s，远端收缩积分（DCI）141.6- 3，674 mmHg·s·cm，远端收缩潜伏期（DL）6.2-8.7 s，积分舒张压（IRP 4s）1.0-18.8 mmHg。水灌注HRM和固态HRM的平均值（SD）和ICC为4.4（1.1）与3.9（0.9）cm/s，ICC：CFV为0.49; 1，189（1，023）vs. 1，092（1，019）mmHg·s·cm，DCI为ICC：0.90; 7.4（0.8）对6.9（0.9）s，ICC：DL为0.50; IRP 4s为8.1（4.8）对7.9（5.1），ICC：0.39。该水灌注HRM系统的正常值与先前发表的固态HRM值仅略有不同，并且在两个系统之间观察到中度至良好的一致性，结果测量仅存在微小差异。
Kessing BF, Weijenborg PW, Smout AJ, Hillenius S, Bredenoord AJ. Water-perfused esophageal high-resolution manometry; normal values and validation. Am J Physiol Gastrointest Liver Physiol 306: G491–G495, 2014. First published January 30, 2014; doi:10.1152/ajpgi.00447.2013.—Water-perfused high-resolution manometry (HRM) catheters with 36 unidirectional pressure channels have recently been developed, but normal values are not yet available. Furthermore, the technique has not been validated and compared with solid-state HRM. We therefore aimed to develop normal values for water-perfused HRM and to assess the level of agreement between water-perfused HRM and solid-state HRM. We included 50 healthy volunteers (mean age 35 yr, range 21–64 yr; 15 women, 35 men). Water-perfused HRM and solid-state HRM were performed in a randomized order. Normal values were calculated as 5th and 95th percentile ranges, and agreement between the two systems was assessed with intraclass correlation coefficient (ICC) statistics. The 5th–95th percentile range was 3.0–6.6 cm/s for contractile front velocity (CFV), 141.6–3,674 mmHg·s·cm for distal contractile integral (DCI), 6.2–8.7 s for distal contraction latency (DL), and 1.0–18.8 mmHg for integrated relaxation pressure (IRP 4s). Mean (SD) and ICC for water-perfused HRM and solid-state HRM were 4.4 (1.1) vs. 3.9 (0.9) cm/s, ICC: 0.49 for CFV; 1,189 (1,023) vs. 1,092 (1,019) mmHg·s·cm, ICC: 0.90 for DCI; 7.4 (0.8) vs. 6.9 (0.9) s, ICC: 0.50 for DL; and 8.1 (4.8) vs. 7.9 (5.1), ICC: 0.39 for IRP 4s. The normal values for this water-perfused HRM system are only slightly different from previously published values with solid-state HRM, and moderate to good agreement was observed between the two systems, with only small differences in outcome measures.