Postnatal Maturation of Skin Barrier Function in Premature Infants
Postnatal Maturation of Skin Barrier Function in Premature Infants
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DOI：
10.1159/000354923
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发表时间：
2014-01-01
影响因子：
2.7
通讯作者：
Bartels, N. Garcia
中科院分区：
文献类型：
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作者：
Kanti, V.;Bonzel, A.;Bartels, N. Garcia
背景：在早产儿中，皮肤屏障的成熟需要区域差异。目的：研究健康早产儿出生后皮肤屏障在覆盖区域、未覆盖区域和尿布区域的纵向观察特征。方法：对48例早产儿(胎龄30~37周，n=48)在出生后1~7天和2~7周时测定其前额、腹部、大腿和臀部皮肤水分损失(TEWL)、角质层水合作用(SCH)、pH和皮脂含量。实行了标准的最低限度皮肤护理养生法。结果：臀部TEWL显著增加(p=0.007)，而额部、腹部和大腿无明显变化。随着年龄的增长，SCH和皮脂在所有被研究的身体部位都保持稳定。臀部pH升高(p=0.049)，其他部位显著降低(p<0.05)。
Background: In preterm infants, skin barrier maturation entails regional variability. Objectives: To characterize postnatal skin barrier development in covered, uncovered and diapered regions in healthy premature infants over a longitudinal observation period. Methods: Transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH and sebum were measured at postnatal ages of 1-7 days and 2-7 weeks on the forehead, abdomen, thigh and buttock of preterm infants (gestational age 30-37 weeks; n = 48) under monitored ambient conditions. A standard minimal skin care regimen was practised. Results: TEWL increased significantly on the buttock (p = 0.007), while remaining stable on the forehead, abdomen and thigh. SCH and sebum remained stable in all studied body regions with increasing age. On the buttock, pH increased (p = 0.049), while other body regions exhibited a significant decrease (p