Synthetic Morphogenesis: introducing IEEE journal readers to programming living mammalian cells to make structures.
Synthetic Morphogenesis: introducing IEEE journal readers to programming living mammalian cells to make structures.
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DOI：
10.1109/jproc.2021.3137077
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Davies JA
中科院分区：
文献类型：
--
作者：
Davies JA
合成形态发生是一门新的工程学科，其中细胞被遗传工程改造成设计的形状和结构。至少在这个领域的早期阶段，设备倾向于利用胚胎发育中的自然形状生成过程，但有时会人工调用它们，并按照技术人员的选择顺序。这需要构建与电子设计密切相关的遗传控制，测序和反馈系统，这也是IEEE期刊读者可能感兴趣的原因之一。另一个原因是，合成形态发生允许在生物和电子之间构建双向接口，特别是光遗传和光电接口，允许两种类型的“机器”之间前所未有的信息流和控制。这篇综述介绍了合成形态发生，说明了已经取得的成就，在生物学和电子学之间尽可能地画出了相似之处，并期待着可能的下一步和要克服的挑战。
Synthetic morphogenesis is a new engineering discipline, in which cells are genetically engineered to make designed shapes and structures. At least in this early phase of the field, devices tend to make use of natural shape-generating processes that operate in embryonic development, but invoke them artificially at times and in orders of a technologist’s choosing. This requires construction of genetic control, sequencing and feedback systems that have close parallels to electronic design, which is one reason the field may be of interest to readers of IEEE journals. The other reason is that synthetic morphogenesis allows the construction of two-way interfaces, especially opto-genetic and opto-electronic, between the living and the electronic, allowing unprecedented information flow and control between the two types of ‘machine’. This review introduces synthetic morphogenesis, illustrates what has been achieved, drawing parallels wherever possible between biology and electronics, and looks forward to likely next steps and challenges to be overcome.