Quality of life in multiple sclerosis: Does information-processing speed have an independent effect?
Quality of life in multiple sclerosis: Does information-processing speed have an independent effect?
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DOI：
10.1016/j.acn.2005.08.008
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发表时间：
2006-02-01
影响因子：
2.6
通讯作者：
Barker-Collo, SL
中科院分区：
文献类型：
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作者：
Barker-Collo, SL
信息处理速度（IPS）已被确定为多发性硬化症的主要缺陷领域，无论疾病的过程。本研究探讨了信息处理速度对多发性硬化（MS）患者生活质量（SF-36测量）的影响程度，与神经功能障碍水平（扩展残疾状态量表（EDSS）测量）无关。52例MS患者（29例复发缓解型和23例原发进展型）完成了SF-36和与处理速度相关的神经心理学测量，并使用EDSS进行评估。EDSS与SF-36中除心理健康和角色限制-情绪外的所有量表均显著相关。虽然EDSS对SF-36分量评分的预测有显著贡献，但将IPS测量值添加到回归方程中并没有显著改善预测。然而，值得注意的是，与增加IPS评分相关的效应量很大，表明生活质量确实与IPS指标相关。(c)2005年美国国家神经心理学学会。由爱思唯尔有限公司出版。保留所有权利。
Information-processing speed (IPS) has been identified as an area of primary deficit in multiple sclerosis regardless of disease Course. This study examines the extent to which information-processing speed contributes to quality of life (measured by the SF-36) in individuals with Multiple Sclerosis (MS), independent of level of neurological disability (measured by the Expanded Disability Status Scale (EDSS)). Fifty-two individuals with MS (29 relapsing-remitting and 23 primary-progressive) completed the SF-36 and neuropsychological measures related to speed of processing and were assessed using the EDSS. The EDSS was significantly related to all SF-36 scales except those measuring Mental Health and Role Limits-Emotional. While the EDSS contributed significantly to prediction of SF-36 component scores, addition of measures of IPS to the regression equation did not significantly improve prediction. It was noted, however, the effect size associated with addition of IPS scores were large, indicating that quality of life is indeed related to measures of IPS. (c) 2005 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.