Cell dynamics of undifferentiated carcinomas of the ovary. Immunohistochemical estimation of their growth fraction and apoptotic status.
Cell dynamics of undifferentiated carcinomas of the ovary. Immunohistochemical estimation of their growth fraction and apoptotic status.
复制标题
卵巢未分化癌的细胞动力学。
DOI：
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发表时间：
1995
影响因子：
0.4
通讯作者：
K. Kishi
中科院分区：
文献类型：
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作者：
Y. Kuwashima;T. Uehara;M. Kurosumi;K. Shiromizu;M. Matsuzawa;K. Kishi
用Ki-67增殖抗原和Le（Y）凋亡抗原抗体，以免疫组化方法检测卵巢未分化癌的增殖和凋亡状态。高分化类型的卵巢癌进行了比较。在8例未分化癌中，增殖活性以Ki-67抗原阳性细胞核百分比表示的生长分数为28.2%至81.2%（平均60%）。在高分化癌中，包括8例浆液性腺癌、8例粘液性腺癌、4例类浆液性腺癌和4例透明细胞腺癌，生长分数范围为8.2%至33.4%（平均20%）。因此，未分化和高分化卵巢癌之间的增殖活性存在统计学显著差异。另一方面，通过Le（Y）染色估计的凋亡状态在未分化癌组和分化癌组中的病例之间变化很大。然而，在一般情况下，未分化癌似乎更容易凋亡比分化良好的癌。它的结论是，在卵巢未分化癌，更活跃的细胞增殖发生伴随细胞损失相比，他们的分化对应。
The proliferative and apoptotic status of undifferentiated carcinomas of the ovary was estimated immunohistochemically by antibody for Ki-67 proliferative antigen and Le(Y) apoptotic antigen. Well-differentiated types of ovarian carcinoma were examined for comparison. In 8 cases of undifferentiated carcinomas, the proliferative activity in terms of the growth fraction expressed as percentage of positive nuclei for Ki-67 antigen ranged from 28.2 to 81.2% (mean 60%). In well-differentiated carcinomas, which included 8 serous, 8 mucinous, 4 endometrioid and 4 clear cell adenocarcinomas, the growth fraction ranged from 8.2 to 33.4% (mean 20%). Thus, statistically significant differences were found in the proliferative activity between undifferentiated and well-differentiated ovarian carcinomas. On the other hand, apoptotic status as estimated by Le(Y) staining varied considerably among the cases in both undifferentiated and differentiated carcinoma groups. Nevertheless, in general, undifferentiated carcinomas seemed to be more prone to apoptosis than well-differentiated carcinomas. It is concluded that in ovarian undifferentiated carcinomas, more active cell proliferation takes place with a concomitant cell loss compared to their differentiated counterparts.