Histamine and asthma.
Histamine and asthma.
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组胺和哮喘。
DOI：
10.1164/arrd.1987.135.5.1165
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Kaliner,MA
中科院分区：
文献类型：
--
作者：
White,MV;Slater,JE;Kaliner,MA
1911年Dale和Laidlaw首次发现组胺是一种有效的血管活性物质(1)，但直到1953年才发现组胺与组织肥大细胞有关(2)。在过去的75年里，人们对组胺进行了广泛的研究，特别是在过去的十年里，因为组胺通过Hl和H-2受体的作用已经变得清晰。在这篇综述中，我们将重点介绍组胺的生物合成和生物降解的最新概念，从肥大细胞和嗜碱性细胞中释放组胺的生理学，以及组胺对靶细胞和组织的作用。在本次讨论的过程中，我们将重点关注组胺在哮喘中的作用，以及组胺可能导致哮喘患者生理改变的机制。
Histamine was first observed to be a potent vasoactive substance by Dale and Laidlaw in 1911 (1) but was not associated with tissue mast cells until 1953 (2). Over the past 75 yr, histamine has been studied extensively, particularly in the past decade since the appreciation of histamine's actions through Hl and H-2 receptors has become clear. In this review, we will focus upon current concepts of the biosynthesis and biodegradation of histamine, the physiology of its release from mast cells and basophils, and the actions of histamine on target cells and tissues. In the course of this discussion, we will focus on the role of histamine in asthma and the mechanisms by which histamine may contribute to the physiologic alterations seen in asthmatic patients.