A controlled-release microchip
A controlled-release microchip
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DOI：
10.1038/16898
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发表时间：
1999-01-28
期刊：
影响因子：
64.8
通讯作者：
Langer, R
中科院分区：
文献类型：
--
作者：
Santini, JT;Cima, MJ;Langer, R
以前在实现复杂药物释放模式的方法中的许多工作都集中在聚合物材料响应特定刺激 (1) 的脉冲释放，例如电场 (2-5) 或磁场 (6,7) 场、暴露于超声波 (7,8)、光 (9) 或酶 (10) 以及 pH (11) 或温度 (12-14) 的变化。实现脉冲释放的另一种方法涉及使用 微制造技术开发有源装置，其中包含微米级泵、阀门和流道以提供液体溶液(15,16)。在这里，我们报告了一种固态硅微芯片，可以根据需要控制释放单一或多种化学物质。释放机制基于覆盖微储存器的薄阳极膜的电化学溶解，微储存器填充有固体、液体或凝胶形式的化学物质。我们使用金和盐溶液作为模型电极材料和释放介质，利用原型微芯片进行了原理验证释放研究，并证明了使用该装置可以控制化学物质的脉冲释放。
Much previous work in methods of achieving complex drug-release patterns has focused on pulsatile release from polymeric materials in response to specific stimuli(1), such as electric(2-5) or magnetic(6,7) fields, exposure to ultrasound(7,8), light(9) or enzymes(10), and changes in pH(11) or temperature(12-14), An alternative method for achieving pulsatile release involves using microfabrication technology to develop active devices that incorporate micrometre-scale pumps, valves and flow channels to deliver liquid solutions(15,16). Here we report a solid-state silicon microchip that can provide controlled release of single or multiple chemical substances on demand. The release mechanism is based on the electrochemical dissolution of thin anode membranes covering microreservoirs filled with chemicals in solid, liquid or gel form. We have conducted proof-of-principle release studies with a prototype microchip using gold and saline solution as a model electrode material and release medium, and we have demonstrated controlled, pulsatile release of chemical substances with this device.