Sansalvamide: A new cytotoxic cyclic depsipeptide produced by a marine fungus of the genus Fusarium
Sansalvamide: A new cytotoxic cyclic depsipeptide produced by a marine fungus of the genus Fusarium
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DOI：
10.1016/s0040-4039(99)00393-7
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发表时间：
1999-04-09
影响因子：
1.8
通讯作者：
Fenical, W
中科院分区：
文献类型：
--
作者：
Belofsky, GN;Jensen, PR;Fenical, W
本文报道了一种新的环五缩酚肽sansalvamide（1），它是从海藻盐藻（Halocelluswrightii）表面采集的镰刀菌属真菌菌丝体的有机提取物中分离得到的。通过对1D和2D NMR数据的广泛分析确定了1的结构。山萨尔瓦多胺对科洛205结肠癌和SK-MEL-2黑色素瘤癌细胞系表现出选择性的体外细胞毒性。(C)1999爱思唯尔科技有限公司。保留所有权利。
A new cyclic pentadepsipeptide, sansalvamide (1), has been isolated from organic extracts of the mycelium of a fungus of the genus Fusarium collected from the surface of the seagrass Halodule wrightii. The structure of 1 was determined through extensive analysis of 1D and 2D NMR data. Sansalvamide exhibited selective in vitro cytotoxicity toward COLO 205 colon and SK-MEL-2 melanoma cancer cell lines. (C) 1999 Elsevier Science Ltd. All rights reserved.