Effects of aging on slow-wave sleep dynamics and human spatial navigational memory consolidation.
Effects of aging on slow-wave sleep dynamics and human spatial navigational memory consolidation.
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DOI：
10.1016/j.neurobiolaging.2016.03.008
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发表时间：
2016-06
影响因子：
4.2
通讯作者：
Ayappa I
中科院分区：
文献类型：
--
作者：
Varga AW;Ducca EL;Kishi A;Fischer E;Parekh A;Koushyk V;Yau PL;Gumb T;Leibert DP;Wohlleber ME;Burschtin OE;Convit A;Rapoport DM;Osorio RS;Ayappa I
睡眠期间空间导航记忆的巩固得到了电生理和行为证据的支持。调节这种能力的睡眠特征可能会随着年龄的增长而改变，因为慢波睡眠的百分比被认为会随着年龄的增长而减少，慢波被认为有助于协调支持系统水平巩固的大脑皮层-新皮层对话。在这项研究中，年轻和年长的受试者在多导睡眠图记录睡眠之前和之后进行了3D空间迷宫导航任务的定时试验。尽管年轻受试者在基线时的表现好于老年受试者，但两组在睡前试验中表现出相似的改善。然而，年轻的受试者在睡眠期间的迷宫表现有显着改善，而在老年受试者中没有观察到，两组之间的早晨精神警觉性没有差异。老年受试者的睡眠质量以慢波睡眠量减少和慢波睡眠碎片增加为标志，导致慢波活动减少。在所有受试者中，额叶慢波活动与夜间迷宫表现和内侧前额叶皮质体积的变化呈正相关，阐明了慢波活动随年龄变化的潜在神经解剖学基础，并强调了慢波活动在睡眠依赖性空间导航记忆巩固中的重要性。
The consolidation of spatial navigational memory during sleep is supported by electrophysiological and behavioral evidence. The features of sleep that mediate this ability may change with aging, as percentage of slow wave sleep is canonically thought to decrease with age, and slow waves are thought to help orchestrate hippocampal-neocortical dialogue that supports systems level consolidation. In this study, groups of younger and older subjects performed timed trials before and after polysomnographically recorded sleep on a 3D spatial maze navigational task. Although younger subjects performed better than older subjects at baseline, both groups showed similar improvement across pre-sleep trials. However, younger subjects experienced significant improvement in maze performance during sleep that was not observed in older subjects, without differences in morning psychomotor vigilance between groups. Older subjects had sleep quality marked by decreased amount of slow wave sleep and increased fragmentation of slow wave sleep, resulting in decreased slow wave activity. Across all subjects, frontal slow wave activity was positively correlated with both overnight change in maze performance and medial prefrontal cortical volume, illuminating a potential neuroanatomical substrate for slow wave activity changes with aging and underscoring the importance of slow wave activity in sleep-dependent spatial navigational memory consolidation.