The effect of flavin adenine dinucleotide on the electroencephalogram modified by chlorpromazine
The effect of flavin adenine dinucleotide on the electroencephalogram modified by chlorpromazine
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黄素腺嘌呤二核苷酸对氯丙嗪修饰脑电图的影响
DOI：
10.1111/j.1471-4159.1960.tb13368.x
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发表时间：
1960
影响因子：
4.7
通讯作者：
T. Nagatsu
中科院分区：
文献类型：
--
作者：
K. Yagi;T. Ozawa;M. Ando;T. Nagatsu
初步研究发现，氯丙嗪对氨基酸氧化酶有抑制作用。用纯化的氧化酶系统进行动力学研究，结果表明，氯丙嗪与黄嘌呤腺嘌呤二核苷酸（FAD）结合为酶蛋白，其解离常数为2.3 × M（YAGI，NAGATSU和OUWA，1956）。最近已经发现，在上述实验中使用的浓度高于10-8 M的氯丙嗪抑制FAD的荧光，作为两种物质的直接复合物形成的ICU（YAOI，OZAWA和NACAISU，1959）。作者认为FAD可能通过这两种药物来阻断氯丙嗪的靶向作用。是.竞争和复杂的结构。FAD和ni 5 '（FM）在DA氨基酸氧化酶系统（EGAMI和YAGI，1！HQ wu .ho记录了脑功能的变化，如脑电图（EEG）（MUMMAW，ANDO，NAOATSIJ和YMI，1958），并记录了各种黄素衍生物的数量与它们对EEG的影响之间的一些有趣的关系（Muurursv. ANW。NAOAW和YAOI。1959年）。FAD和氯丙嗪的作用是相互对立的。因此，我们从以下几个方面研究了FAD对氯丙嗪修饰脑电图的影响：
~n AN eadicr study it was found that chlorpromszine inhibited amino acid oxidase. The experimental mdu OMnimd by kinaic study using a purified oxidase system showed that the chlorpromazine compcccd with thc flavio adenim dinuchtide (FAD) for the enzyrne protein, and the dissociation conrtlnt of ~ ~ ~ ~ r o t c i n annpkx was found to be 2.3 x M (YAGI, NAGATSU .nd OUWA, 1956). Recently. it has been found that chlorpromazine at higher concentration than 10-8 M, which was uscd in the abowmentioned experiment, inhibited the fluorescena of FAD as a ICU& of direct compkx formation of both substaoces (YAOI, OZAWA and NACAISU, 1959). Accordiagtr, it waa thought that FAD might dccrcasc the action of chlorpromazine in aim by these two -. is. competition and complex formation. The antagonistic action of FAD and n i 5 ’ (FM) found in the Damino acid oxidase system (EGAMI and YAGI, 1!HQ wu .ho rdbdcd in f u n a i d pbeMnnena of tbe brain, such as the electroencephalogram @rjc) (MUMMAW, ANDO, NAOATSIJ and YMI, 1958), and some interesting relationships between the Qemialof tbe various flavin duivatives and their influence on the EEG were noted (Muurursv. ANW. NAOAW d YAOI. 1959). Thae d t a suggestsd that tbe actions of FAD and chlorpromazine are opposed to each ochr In obo. Tbe effect of FAD on the EEG modified by chlorpromazine was therefore studied from